Results 131 to 140 of about 17,182,321 (391)
Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures
Stem Cell Research & Therapy, 2018 Background Senescent cells are undesirable in cell therapy products due to reduced therapeutic activity and risk of aberrant cellular effects, and methods for assessing senescence are needed. Early-passage mesenchymal stromal cells (MSCs) are known to be
S. Oja +4 more
doaj +1 more source
Mesenchymal stem cells: Cell therapy and regeneration potential
Journal of Tissue Engineering and Regenerative Medicine, 2019 Rapid advances in the isolation of multipotent progenitor cells, routinely called mesenchymal stromal/stem cells (MSCs), from various human tissues and organs have provided impetus to the field of cell therapy and regenerative medicine.
Christina Brown +9 more
semanticscholar +1 more source
Clinical Trials of Stem Cell Therapy for Cerebral Ischemic Stroke
International Journal of Molecular Sciences, 2020 Despite recent developments in innovative treatment strategies, stroke remains one of the leading causes of death and disability worldwide. Stem cell therapy is currently attracting much attention due to its potential for exerting significant therapeutic
M. Kawabori +3 more
semanticscholar +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers [PDF]
, 2005 Stem cell transplantation is used widely in the management of a range of diseases of the hemopoietic system. Patients are immunosuppressed profoundly in the early posttransplant period, and reactivation of cytomegalovirus (CMV) remains a significant ...
Assenmacher, Mario +15 more
core +5 more sources
Contributions of HOX genes to cancer hallmarks: Enrichment pathway analysis and review
Tumor Biology, 2020 Homeobox genes function as master regulatory transcription factors during development, and their expression is often altered in cancer. The HOX gene family was initially studied intensively to understand how the expression of each gene was involved in ...
Danielle Barbosa Brotto +11 more
doaj +1 more source
An acute immune response underlies the benefit of cardiac stem cell therapy
Nature, 2019 Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this day 1 , 2 , despite ongoing questions of efficacy and a lack of mechanistic understanding of the underlying biological effect 3 .
Ronald J. Vagnozzi +10 more
semanticscholar +1 more source
Mesenchymal Stem Cell Therapy for COVID-19: Present or Future
Stem Cell Reviews and Reports, 2020 “COVID-19” is the word that certainly isn’t forgotten by everybody who lives in the first half of the twenty-first century. COVID-19, as a pandemic, has led many researchers from different biomedical fields to find solutions or treatments to manage the ...
A. Golchin +2 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Regulatory T-cell therapy in Crohn’s disease: challenges and advances
Gut, 2020 The prevalence of IBD is rising in the Western world. Despite an increasing repertoire of therapeutic targets, a significant proportion of patients suffer chronic morbidity.
J. Clough +4 more
semanticscholar +1 more source