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Veterinary Clinics of North America: Small Animal Practice, 2019
The necessity of improving the health and quality of life of subjects affected by diverse injuries and chronic diseases, has led to develop a new branch of translational medicine, called Regenerative Medicine (RegMed). RegMed has the principal objects of restoring, maintaining or enhancing structures and functions of tissues and organs.
De Falco E. +3 more
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The necessity of improving the health and quality of life of subjects affected by diverse injuries and chronic diseases, has led to develop a new branch of translational medicine, called Regenerative Medicine (RegMed). RegMed has the principal objects of restoring, maintaining or enhancing structures and functions of tissues and organs.
De Falco E. +3 more
openaire +4 more sources
Cell therapies for glioblastoma
Expert Opinion on Biological Therapy, 2006Malignant gliomas, including the most devastating type, glioblastoma multiforme (GBM), are characterised by their local growth and aggressive infiltration of the normal brain. GBMs result in a profound disability, leading to death in almost all cases. There has been little improvement in outcome despite intensive clinical and laboratory research during
Simone P. Niclou +4 more
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Current Opinion in Biotechnology, 1996
In the past year, a number of human gene therapy trials involving the adoptive transfer of genetically modified T lymphocytes have been reported. These include trials of adenosine deaminase gene transfer in children with severe combined immunodeficiency syndrome, a gene-marking study of Epstein-Barr virus-specific cytotoxic T cells, and trials of gene ...
Margo R. Roberts, Kristen Hege
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In the past year, a number of human gene therapy trials involving the adoptive transfer of genetically modified T lymphocytes have been reported. These include trials of adenosine deaminase gene transfer in children with severe combined immunodeficiency syndrome, a gene-marking study of Epstein-Barr virus-specific cytotoxic T cells, and trials of gene ...
Margo R. Roberts, Kristen Hege
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cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy
Science Translational Medicine, 2020Cell-intrinsic cGAS-STING–mediated DNA sensing promotes the formation of stem cell–like CD8+ T cells for effective cancer T cell therapy. Intuitive CD8+ T cells sense DNA Stimulator of interferon genes (STING) agonism is an area of active exploration for
Wenwen Li +16 more
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Science, 2018 Synthetic Notch receptors expand the therapeutic potential of engineered T ...
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CAR T‐Cell Therapy in Hematologic Malignancies: A Voyage in Progress
Clinical pharmacology and therapy, 2020The development of chimeric antigen receptor (CAR) T‐cell therapy for select hematological malignancies represents one of the most remarkable therapeutic advances in the past decade.
S. Holstein, M. Lunning
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2013
Since the start of the international project in 1997, over 2000 patients have received a haematopoietic stem cell transplant (HSCT), mostly autologous, as treatment for a severe autoimmune disease, with overall 85% 5-year survival and 43% progression-free survival.
Alan Tyndall, Jacob M. van Laar
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Since the start of the international project in 1997, over 2000 patients have received a haematopoietic stem cell transplant (HSCT), mostly autologous, as treatment for a severe autoimmune disease, with overall 85% 5-year survival and 43% progression-free survival.
Alan Tyndall, Jacob M. van Laar
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1996
Peripheral blood has replaced bone marrow as a source of hematopoietic stem cells for autologous rescue after high‐dose chemotherapy. Patients who receive peripheral blood stem cell (PBSC) transplants experience rapid and sustained hematopoietic reconstitution.
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Peripheral blood has replaced bone marrow as a source of hematopoietic stem cells for autologous rescue after high‐dose chemotherapy. Patients who receive peripheral blood stem cell (PBSC) transplants experience rapid and sustained hematopoietic reconstitution.
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Expert Opinion on Biological Therapy, 2008
Management of chronic pain remains a challenge in spite of numerous drugs that are either approved or still in development. Apart from inadequate relief, there are concerns about adverse effects and addiction. Cell therapy is being explored for relief of pain.To address the rationale for cell therapy for treatment of pain and its advantages over ...
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Management of chronic pain remains a challenge in spite of numerous drugs that are either approved or still in development. Apart from inadequate relief, there are concerns about adverse effects and addiction. Cell therapy is being explored for relief of pain.To address the rationale for cell therapy for treatment of pain and its advantages over ...
openaire +3 more sources