Results 51 to 60 of about 17,214,210 (344)

Potential and challenges of specifically isolating extracellular vesicles from heterogeneous populations

Scientific Reports, 2021
Extracellular vesicles (EVs) have attracted interest due to their ability to provide diagnostic information from liquid biopsies. Cells constantly release vesicles divers in size, content and features depending on the biogenesis, origin and function ...
Susann Allelein, Paula Medina-Perez, Ana Leonor Heitor Lopes, Sabrina Rau, Gerd Hause, Andreas Kölsch, Dirk Kuhlmeier   +6 more
doaj   +1 more source

Anti‐BCMA CAR T‐Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma

New England Journal of Medicine, 2019
BACKGROUND Preclinical studies suggest that bb2121, a chimeric antigen receptor (CAR) T‐cell therapy that targets B‐cell maturation antigen (BCMA), has potential for the treatment of multiple myeloma. METHODS In this phase 1 study involving patients with
N. Raje, J. Berdeja, Yi Lin, D. Siegel, S. Jagannath, D. Madduri, M. Liedtke, J. Rosenblatt, M. Maus, Ashley Turka, L. Lam, R. Morgan, Kevin G. Friedman, M. Massaro, Julie Wang, G. Russotti, Zhihong Yang, T. Campbell, K. Hege, F. Petrocca, Travis Quigley, N. Munshi, J. Kochenderfer   +22 more
semanticscholar   +1 more source

Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]

, 2016
Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai, Liu, Yan-Qun, Xie, Chong, Zhang, Guang-Xian   +3 more
core   +2 more sources

Fetal Tissues Tested for Microbial Sterility by Culture- and PCR-Based Methods Can be Safely Used in Clinics

Cell Transplantation, 2017
Cell preparations to be used in clinical practice must be free of infectious agents. Safety concerns are especially elevated upon the use of human fetal tissues, which are otherwise highly advantageous in cell therapy.
Yakov Vitrenko, Iryna Kostenko, Kateryna Kulebyakina, Alla Duda, Mariya Klunnyk, Khrystyna Sorochynska   +5 more
doaj   +1 more source

Identification of very early inflammatory markers in a porcine myocardial infarction model

BMC Veterinary Research, 2019
Background Acute myocardial infarction (AMI) is one of the most deleterious conditions leading to cardiovascular diseases and mortality. The importance of an early and accurate diagnosis assures immediate medical treatments, which are fundamental to ...
Esther López, Francisco Miguel Sánchez-Margallo, Verónica Álvarez, Rebeca Blázquez, Federica Marinaro, Ana Abad, Helena Martín, Claudia Báez, Virginia Blanco, Verónica Crisóstomo, Javier García Casado   +10 more
doaj   +1 more source

Current Progress in CAR-T Cell Therapy for Hematological Malignancies

Journal of Cancer, 2021
Immunotherapies, such as monoclonal antibody therapy and checkpoint inhibitor therapy, have shown inspiring clinical effects for the treatment of cancer.
Donglei Han, Zeng-hui Xu, Zhuang Yuan, Zhen-long Ye, Q. Qian   +4 more
semanticscholar   +1 more source

Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing

Molecular Cancer, 2023
Background Chimeric Antigen Receptor (CAR) T cells are now standard of care (SOC) for some patients with B cell and plasma cell malignancies and could disrupt the therapeutic landscape of solid tumors.
Hyatt Balke-Want, Vimal Keerthi, Nikolaos Gkitsas, Andrew G. Mancini, Gavin L. Kurgan, Carley Fowler, Peng Xu, Xikun Liu, Kyle Asano, Sunny Patel, Christopher J. Fisher, Annie K. Brown, Ramya H. Tunuguntla, Shabnum Patel, Elena Sotillo, Crystal L. Mackall, Steven A. Feldman   +16 more
doaj   +1 more source

Mesenchymal stem cell-based therapy for ischemic stroke [PDF]

, 2016
Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available.
Anderson, JD, Bardini, RL, Bauer, G, Bramlett, CS, Chedin, F, Contreras, Z, Dunbar, GL, El-Andaloussi, S, Fiehn, O, Fink, KD, Fury, B, Hendrix, KJ, Hoon, M, Hwang, B, Johansson, HJ, Lehtiö, J, Mulligan, MS, Nolta, JA, Pham, MT, Rossignol, J, Showalter, M   +20 more
core   +2 more sources

Three doses of a recombinant conjugated SARS-CoV-2 vaccine early after allogeneic hematopoietic stem cell transplantation: predicting indicators of a high serologic response—a prospective, single-arm study

Frontiers in Immunology, 2023
BackgroundAllogeneic hematopoietic stem cell transplant (allo-HSCT) recipients must be vaccinated against SARS-CoV-2 as quickly as possible after transplantation.
Maryam Barkhordar, Bahram Chahardouli, Alireza Biglari, Mohammad Ahmadvand, Tanaz Bahri, Farshid Alaeddini, Leyla Sharifi Aliabadi, Seied Saeid Noorani, Fahimeh Bagheri Amiri, Mohammad Biglari, Mohammad Reza Shemshadi, Ardeshir Ghavamzadeh, Mohammad Vaezi   +12 more
doaj   +1 more source

Reactions Related to CAR-T Cell Therapy

Frontiers in Immunology, 2021
The application of chimeric antigen receptor (CAR) T-cell therapy as a tumor immunotherapy has received great interest in recent years. This therapeutic approach has been used to treat hematological malignancies solid tumors.
Lele Miao, Zhengchao Zhang, Zhijian Ren, Yumin Li   +3 more
semanticscholar   +1 more source