Results 71 to 80 of about 3,606,010 (253)

Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer [PDF]

, 2018
Background Endocrine therapies are the mainstay of treatment for oestrogen receptor (ER)-positive (ER+) breast cancer (BC). However, resistance remains problematic largely due to enhanced cross-talk between ER and growth factor pathways, circumventing ...
A Carracedo, A Subramanian, AH Evans, Allan Thornhill, Alshad S. Lalani, Aradhana Rani, C Trapnell, CK Osborne, CX Ma, Eugene Schuster, FL Chen, Francesca Avogadri-Connors, G Arpino, HJ Burstein, IE Smith, J Baselga, Joanna Nikitorowicz-Buniak, KE Bachman, KE O'Reilly, L Gandhi, LA Martin, LA Martin, Lesley-Ann Martin, LV Sequist, M Arnedos, M Dowsett, Mitch Dowsett, MT Weigel, N Patani, N Simigdala, NA O'Brien, Nikiana Simigdala, R Ribas, Ricardo Ribas, Richard E. Cutler, S Johnston, SC Drury, SN Mohd Nafi, SP Newman, Stephanie K. Guest, Stephen R. Johnston, Sunil Pancholi, T Nagashima, W Luo   +43 more
core   +6 more sources

Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy including senscence, necrosis, and autophagy, but not apoptosis [PDF]

, 2015
In comparison to more differentiated cells, prostate cancer stem-like cells are radioresistant, which could explain radio-recurrent prostate cancer. Improvement of radiotherapeutic efficacy may therefore require combination therapy.
Boyle, Ross W., Bryden, Francesca, Frame, Fiona M., Giuntini, Francesca, Maitland, Norman J., Mann, Vincent M., Savoie, Huguette, Simms, Matthew S.   +7 more
core   +1 more source

Identification of Donor Origin and Condition of Transplanted Islets in Situ in the Liver of a Type 1 Diabetic Recipient

Cell Transplantation, 2017
Transplantation of islet allografts into type 1 diabetic recipients usually requires multiple pancreas donors to achieve insulin independence. This adds to the challenges of immunological monitoring of islet transplantation currently relying on surrogate
Cornelis R. Van Der Torren, Jessica S. Suwandi, Dahae Lee, Ernst-Jan T. Van't Wout, Gaby Duinkerken, Godelieve Swings, Arend Mulder, Frans H. J. Claas, Zhidong Ling, Pieter Gillard, Bart Keymeulen, Peter In't Veld, Bart O. Roep   +12 more
doaj   +1 more source

Fabrication of viable cyborg cells with cyclodextrin functionality [PDF]

, 2013
We describe two alternative methods for surface functionalisation of Saccharomyces cerevisiae cells with cyclodextrin molecules without affecting the cell viability.
Mathapa, Baghali G., Paunov, Vesselin N.
core   +1 more source

Recent progress in stem cell and immune cell-based interventions for aging and age-related disorders

Frontiers in Aging
The extension of human lifespan has intensified the demand for developing more effective strategies to enhance quality of life. Age-related physiological decline and associated diseases now constitute significant societal challenges.
Li He, Donglei Han, Fenfen Zong, Yan Zhang, Zhongyang Han, Zenghui Xu, Zenghui Xu, Zenghui Xu   +7 more
doaj   +1 more source

Intracellular localisation of mTHPC and effect of photodynamic therapy in cells of the mammalian peripheral nervous system [PDF]

, 2007
Fewer nerve-related side effects have been noted after treating head and neck cancer with photodynamic therapy (PDT) compared to conventional cancer therapy. Our aim is to investigate the biological basis for any such nerve-sparing effect.
MacRobert, A. J., Phillips, J. B., Wright, K. E.   +2 more
core  

A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]

, 2016
mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat, Califano, Joseph A, Callejas-Valera, Juan Luis, Cohen, Ezra E, Gutkind, J Silvio, Iglesias-Bartolomé, Ramiro, Lippman, Scott M, Luo, Ji, Molinolo, Alfredo A, Wang, Zhiyong, Yamaguchi, Kosuke   +10 more
core   +1 more source

Optimizing the Banking and Releasing Strategies of Clinical-Grade HLA-Homozygous Human iPSCs for Regenerative Medicine

Stem Cells International
Since their initial generation, induced pluripotent stem cells (iPSCs) have attracted considerable attention and undergone rapid development. iPSC-derived cell therapies show great promise in the field of regenerative medicine.
Qianping Zhang, Lijuan Cui, Ying Jia, Xiaohui Shi, Jinmei Zhang, Li Zhang, Zhihui Liu, Yun Zhang, Huizhuan Fu, Qi Qi, Quan Chen, Wei Du, Yu Zhang   +12 more
doaj   +1 more source

Low-liver-accumulation lipid nanoparticles enhance the efficacy and safety of HPV therapeutic tumor vaccines

Journal of Translational Medicine
Background Lipid nanoparticles (LNPs) hold significant potential in vaccine and cancer therapy, but conventional LNPs often cause hepatotoxicity and reduced efficacy due to liver accumulation.
Xiaodie Wang, Zhidan Tian, Meng Wang, Xiaoru Cai, Shuyan Yang, Jianyao Zeng, Yuan Fang, Xuesen Bai, Pei Wang, Yan Sun, Chuanxin Guo, Tao Liu, Qijun Qian   +12 more
doaj   +1 more source

The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction [PDF]

, 2016
Gene therapy has long been regarded as a promising treatment for cancer. However, cancer gene therapy is still facing the challenge of targeting gene delivery vectors specifically to tumors when administered via clinically acceptable non-invasive ...
Albahrani, M, Bentayebi, K, Hajitou, A, Przystal, J, Suwan, K, Tsafa, E   +5 more
core   +2 more sources