Results 81 to 90 of about 3,606,010 (253)

Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures

Stem Cell Research & Therapy, 2018
Background Senescent cells are undesirable in cell therapy products due to reduced therapeutic activity and risk of aberrant cellular effects, and methods for assessing senescence are needed. Early-passage mesenchymal stromal cells (MSCs) are known to be
S. Oja, P. Komulainen, A. Penttilä, J. Nystedt, M. Korhonen   +4 more
doaj   +1 more source

Contributions of HOX genes to cancer hallmarks: Enrichment pathway analysis and review

Tumor Biology, 2020
Homeobox genes function as master regulatory transcription factors during development, and their expression is often altered in cancer. The HOX gene family was initially studied intensively to understand how the expression of each gene was involved in ...
Danielle Barbosa Brotto, Ádamo Davi Diógenes Siena, Isabela Ichihara de Barros, Simone da Costa e Silva Carvalho, Bruna Rodrigues Muys, Lucas Goedert, Cibele Cardoso, Jessica Rodrigues Plaça, Anelisa Ramão, Jeremy Andrew Squire, Luiza Ferreira Araujo, Wilson Araújo da Silva   +11 more
doaj   +1 more source

Alterations of immune response of non-small lung cancer with azacytidine [PDF]

, 2013
Innovative therapies are needed for advanced Non-Small Cell Lung Cancer (NSCLC). We have undertaken a genomics based, hypothesis driving, approach to query an emerging potential that epigenetic therapy may sensitize to immune checkpoint therapy targeting
Baylin, Stephen B, Brahmer, Julie R, Brock, Malcolm V, Carvajal, Richard D, De Meyer, Tim, Du, Zhengzong, Easton, Keith, Easwaran, Hariharan, Jones, Peter A, Juergens, Rosalyn A, Koch, Alexander, Laird, Peter W, Mohammad, Helai P, Pardoll, Drew, Parsana, Princy, Rodgers, Kristen, Rudin, Charles M, Taube, Janis M, Topalian, Suzanne L, Tsai, Salina, Tykodi, Scott S, Van Criekinge, Wim, Vendetti, Frank, Wang, Wei, Weisenberger, Daniel J, Wrangle, John, Yen, Ray-Whay, Zahnow, Cynthia A   +27 more
core   +1 more source

E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor Cells [PDF]

, 2018
RATIONALE: The majority of current cardiovascular cell therapy trials use bone marrow progenitor cells (BM PCs) and achieve only modest efficacy; the limited potential of these cells to differentiate into endothelial-lineage cells is one of the major ...
Boriboun, Chan, Chandel, Navdeep S., Cheng, Min, Dong, Nian-Guo, Harris, Robert A., Huang, Kai, Liu, Qinghua, Losordo, Douglas W., Qin, Gangjian, Qiu, Hongyu, Shi, Jiawei, Sun, Tianjiao, Tao, Jun, Xu, Shiyue, Yang, Liu, Zhang, Eric, Zhao, Ting C., Zhou, Junlan   +17 more
core   +1 more source

HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses. [PDF]

, 2015
Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains ...
Allen, S, Bansal, A, Carlson, J, Dilernia, D, Du, VY, Erdmann, N, Gilmour, J, Goepfert, PA, Heath, S, Hunter, E, Jureka, A, Lakhi, S, Schaefer, M, Sidney, J, Sterrett, S, Tang, J, Yue, L   +16 more
core   +3 more sources

Fermented mistletoe extract as a multimodal antitumoral agent in gliomas [PDF]

, 2012
In Europe, commercially available extracts from the white-berry mistletoe (Viscum album L.) are widely used as a complementary cancer therapy. Mistletoe lectins have been identified as main active components and exhibit cytotoxic effects as well as ...
Harter, Patrick Nikolaus, Mittelbronn, Michel Guy André, Naumann, Ulrike, Podlech, Oliver, Pöschel, Simone   +4 more
core   +2 more sources

Why Extracellular Vesicles Are Attractive Vehicles for RNA-Based Therapies?

SynBio
Extracellular Vesicles (EVs) are a focus of intense research worldwide, with many groups exploring their potential for both diagnostic and therapeutic applications. Researchers have characterized EVs into various subtypes, modified common surface markers,
Farah Aqel, Kristin Schneider, Denise Hartung, Kathrin Schwarz, Olga Shatnyeva   +4 more
doaj   +1 more source

Establishing the cost of implementing a performance-based, managed entry agreement for a hypothetical CAR T-cell therapy

Journal of Market Access & Health Policy, 2018
Background: Market access stakeholders consider the adoption of Managed Entry Agreements (MEAs), however a clearly described methodology to quantify their implementation burden is not available in the public domain.
Panos Kefalas, Omar Ali, Jesper Jørgensen, Nick Merryfield, Tim Richardson, Adam Meads, Laura Mungapen, Matthew Durdy   +7 more
doaj   +1 more source

Posttransplant lymphoproliferative disorders in neuronal xenotransplanted macaques [PDF]

, 2016
Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of lymphoid proliferations that occur in the setting of depressed T-cell function due to immunosuppressive therapy used following solid organ transplantation, hematopoietic ...
Aron Badin, R., Cavicchioli, L., Cozzi, E., Crossan, C., Danesi, A., Ferraresso, S., Hantraye, P., Kaliyaperumal, S., Knight, H., Scobie, L., Trez, D., Vadori, M., Westmoreland, S.   +12 more
core   +1 more source

Therapeutic efficacy of thrombin-preconditioned mesenchymal stromal cell-derived extracellular vesicles on Escherichia coli-induced acute lung injury in mice

Respiratory Research
Background Acute lung injury (ALI) following pneumonia involves uncontrolled inflammation and tissue injury, leading to high mortality. We previously confirmed the significantly increased cargo content and extracellular vesicle (EV) production in ...
Yuna Bang, Sein Hwang, Young Eun Kim, Dong Kyung Sung, Misun Yang, So Yoon Ahn, Se In Sung, Kyeung Min Joo, Yun Sil Chang   +8 more
doaj   +1 more source