Results 201 to 210 of about 816,794 (268)

Exploring new mechanisms in cancer molecular pathways and pathogenic cell transformation: PIP4K2A as a prognostic marker and therapeutic target in cutaneous malignant melanoma. [PDF]

Discov Oncol
Luo WF, Song DM, Shen T, He YB, Du HY, Si MJ, Fang LW.   +6 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Differential carbonic anhydrase activities control EBV-induced B-cell transformation and lytic cycle reactivation. [PDF]

PLoS Pathog
Malik S, Biswas J, Sarkar P, Nag S, Gain C, Ghosh Roy S, Bhattacharya B, Ghosh D, Saha A.   +8 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

The non-vesicle cell-free DNA (cfDNA) induces cell transformation associated with horizontal DNA transfer. [PDF]

Mol Biol Rep
De La Cruz-Sigüenza DA, Reyes-Grajeda JP, Velasco-Velázquez MA, Trejo-Becerril C, Pérez-Cárdenas E, Chávez-Blanco A, Taja-Chayeb L, Domínguez-Gómez G, Ramos-Godinez MP, González-Fierro A, Dueñas-González A.   +10 more
europepmc   +1 more source

Post-therapeutic squamous cell transformation of a metastatic prostate adenocarcinoma with comparison of molecular profiles: a case report and review of the literature. [PDF]

Int J Clin Exp Pathol
Li P, Haines GK, Si Q, Baskovich B.
europepmc   +1 more source

Intralesional doxorubicin as a useful adjunct in the treatment of localized mycosis fungoides tumors with CD30⁺ large cell transformation. [PDF]

JAAD Case Rep
Ho JD, Thomas J, McNish A, Thomas R, Welch J, Dawkins O, Ruddock R, Smith-Matthews S.   +7 more
europepmc   +1 more source

Comparative structural studies on Bovine papillomavirus E6 oncoproteins: Novel insights into viral infection and cell transformation from homology modeling and molecular dynamics simulations. [PDF]

Genet Mol Biol
Santos LABO, Feitosa TAL, Batista MVA.
europepmc   +1 more source