Results 101 to 110 of about 25,291,875 (362)

Lactate Oxidation in Endothelial Cells: A Feature of All Endothelial Cells? [PDF]

, 2019
Resumen de la comunicaciónMetabolism of endothelial cells is a topic that has gained an increasing interest in the last years. This is due to their role in the angiogenic process, which is pathologically upregulated in several diseases, such as ...
Martínez-Poveda, Beatriz, Medina, Miguel Ángel, Ocaña-Ocaña, Maria del Carmen, Quesada, Ana R.   +3 more
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Big Cells, Little Cells, Stem Cells [PDF]

Circulation Research, 2007
See related article, pages 536–544 As of August 2003, the prevailing dogma posited that the heart is a terminally-differentiated organ, that the myocytes we have now are those we were born with (only bigger), and that the best hope for treating cardiac injury is to limit the insult (eg, by prompt reperfusion) or to block secondary maladaptive ...
openaire   +1 more source

Landscape of transcription in human cells

Nature, 2012
Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations ...
S. Djebali, Carrie A. Davis, A. Merkel, A. Dobin, T. Lassmann, A. Mortazavi, Andrea Tanzer, Julien Lagarde, Wei Lin, F. Schlesinger, Chenghai Xue, G. Marinov, Jainab Khatun, B. Williams, C. Zaleski, J. Rozowsky, M. Röder, F. Kokocinski, Rehab F Abdelhamid, T. Alioto, I. Antoshechkin, Michael T. Baer, Nadav S. Bar, P. Batut, Kim Bell, I. Bell, S. Chakrabortty, Xian Chen, Jacqueline Chrast, João Curado, T. Derrien, J. Drenkow, E. Dumais, Jacqueline Dumais, R. Duttagupta, E. Falconnet, Meagan Fastuca, Katalin Fejes-Toth, Pedro G. Ferreira, S. Foissac, M. Fullwood, Hui Gao, David Gonzalez, Assaf Gordon, H. Gunawardena, C. Howald, Sonali Jha, Rory Johnson, P. Kapranov, Brandon King, C. Kingswood, O. J. Luo, Eddie Park, K. Persaud, Jonathan B. Preall, Paolo Ribeca, Brian A Risk, D. Robyr, M. Sammeth, L. Schaffer, L. See, Atif Shahab, Jørgen Skancke, A. Suzuki, Hazuki Takahashi, Hagen U. Tilgner, Diane Trout, Nathalie Walters, Huaien Wang, J. Wrobel, Yanbao Yu, Xiaoan Ruan, Y. Hayashizaki, J. Harrow, M. Gerstein, T. Hubbard, A. Reymond, S. Antonarakis, G. Hannon, Morgan C. Giddings, Y. Ruan, B. Wold, Piero Carninci, R. Guigó, T. Gingeras   +84 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Genetically modified natural killer cells specifically recognizing the tumor-associated antigens ErbB2/HER2 and EpCAM [PDF]

, 2007
The continuously growing natural killer (NK) cell line NK-92 is highly cytotoxic against malignant cells of various origin without affecting normal human cells.
Klingemann, Hans-Georg, Müller, Tina, Tonn, Torsten, Uherek, Barbara, Uherek, Christoph, Wels, Winfried S.   +5 more
core  

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source