Results 191 to 200 of about 9,270,539 (313)

ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis. [PDF]

Cancer Res
Young RG, Esquea EM, Ciraku L, Merzy J, Ahmed NN, Talarico AN, Karuppiah M, Medori SM, Warade RP, Gocal W, Dick A, Simone NL, Reginato MJ.   +12 more
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A Personalized Therapeutic Approach for Liver Cancers Expressing the African-Centric P47S Variant of TP53. [PDF]

Mol Cancer Res
Foster M, Casey K, Cassel J, Ye Y, Diaz J, Shuda McGuire K, Barnoud T, Murphy ME.   +7 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Prostatic fibroblast reprogramming by Interleukin-30 activates prostate cancer metastasis programs. [PDF]

Mol Biomed
Ciummo SL, Sorrentino C, Marchetti S, Fieni C, Lanuti P, Di Carlo E.   +5 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

2-Pyrazoline-5-One Derivative Suppresses Cell Proliferation and Induces Apoptosis With Upregulation of Bax in Breast Cancer Cells. [PDF]

J Biochem Mol Toxicol
Sevinc SK, Küçükgüzel ŞG, Rollas S, Yukcu F.   +3 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

RETRACTION: The DNMT1/miR-34a Axis Is Involved in the Stemness of Human Osteosarcoma Cells and Derived Stem-Like Cells

Stem Cells International
Stem Cells International
doaj   +1 more source

Engineering T cells with a novel PD-L1-specific TCR targeting immune and cancer cells. [PDF]

Signal Transduct Target Ther
Lisle TL, Jacobsen EB, Ahmad SM, Met Ö, Bak RO, Andersen MH.   +5 more
europepmc   +1 more source