Results 21 to 30 of about 359,726 (298)
Disease Models & Mechanisms, 2022 Nucleoporin 98KD (Nup98) is a promiscuous translocation partner in hematological malignancies. Most disease models of Nup98 translocations involve ectopic expression of the fusion protein under study, leaving the endogenous Nup98 loci unperturbed ...
Ajai J. Pulianmackal +6 more
doaj +1 more source
Complete developmental cycle of Leishmania mexicana in axenic culture [PDF]
, 1994 A complete developmental sequence of Leishmania mexicana has been produced in axenic culture for the first time. This was achieved by manipulation of media, pH and temperature conditions over a period of 16 days.
Bates, P A
core +3 more sources
Quantitative analysis of cell shape and the cytoskeleton in developmental biology
, 2020 Computational approaches that enable quantification of microscopy data have revolutionized the field of developmental biology. Due to its inherent complexity, elucidating mechanisms of development requires sophisticated analysis of the structure, shape ...
Martin, Adam C, Yevick, Hannah G.
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Nature Communications, 2019 The daily accumulation of the ZEITLUPE (ZTL) photoreceptor/E3 ubiquitin ligase relies on a light-dependent interaction with GIGANTEA (GI). Here the authors show that GI recruits two deubiquitylases to help stabilize the ZTL-GI complex during the day and ...
Chin-Mei Lee +5 more
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Lithium-sensing riboswitch classes regulate expression of bacterial cation transporter genes
Scientific Reports, 2022 Lithium is rare in Earth’s crust compared to the biologically relevant alkali metal cations sodium and potassium but can accumulate to toxic levels in some environments.
Neil White +4 more
doaj +1 more source
Loss of FTO Antagonises Wnt Signaling and Leads to Developmental Defects Associated with Ciliopathies [PDF]
, 2014 Common intronic variants in the Human fat mass and obesity-associated gene (FTO) are found to be associated with an increased risk of obesity. Overexpression of FTO correlates with increased food intake and obesity, whilst loss-of-function results in ...
Rosa Maria Roccasecca (519728) +40 more
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Nature Communications, 2017 Multiple mechanisms regulate Wnt/ß-catenin signalling. Zhanget al. describe a novel regulatory pathway and show that the activator of canonical Wnt signalling, Norrin, triggers endocytosis of its receptor Frizzled4 by promoting Frizzled4 ubiquitination.
Chi Zhang +5 more
doaj +1 more source
Fsh stimulates Leydig cell Wnt5a production, enriching zebrafish type A spermatogonia [PDF]
, 2018 Follicle-stimulating hormone (Fsh) modulates vertebrate spermatogenesis by regulating somatic cell functions in the testis. We have found previously that zebrafish Fsh stimulated the differentiating proliferation of type A undifferentiated spermatogonia (
Sub Developmental Biology +5 more
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Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii
eLife, 2022 The agricultural pest Drosophila suzukii differs from most other Drosophila species in that it lays eggs in ripe, rather than overripe, fruit. Previously, we showed that changes in bitter taste sensation accompanied this adaptation (Dweck et al., 2021 ...
Wanyue Wang +5 more
doaj +1 more source
Nature Communications, 2021 Parasitoids exploit host bodies for reproduction, selecting for host defences. A new host defence is reported, in which adult Drosophila accelerate mating behaviour at the sight of certain parasitoid wasps, mediated by the upregulation of a nervous ...
Shimaa A. M. Ebrahim +2 more
doaj +1 more source