Results 31 to 40 of about 359,726 (298)
Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition [PDF]
, 2020 Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL).
Lyakisheva, Anna +12 more
core +1 more source
XPO5 promotes primary miRNA processing independently of RanGTP
Nature Communications, 2020 XPO5 mediates nuclear export of miRNA hairpin precursors (pre-miRNAs) through a RanGTP-dependent binding. Here the authors employ HITS-CLIP and biochemical analysis and show that XPO5 binds and promotes nuclear processing of clustered pri-miRNAs, with ...
Jingjing Wang +6 more
doaj +1 more source
Non‐genetic diversity modulates population performance
Molecular Systems Biology, 2016 Biological functions are typically performed by groups of cells that express predominantly the same genes, yet display a continuum of phenotypes. While it is known how one genotype can generate such non‐genetic diversity, it remains unclear how different
Adam James Waite +5 more
doaj +1 more source
Noise reduction as an emergent property of single-cell aging
Nature Communications, 2017 Gene expression is a noisy process, but it is not known how noise in gene expression changes during the aging of single cells. Here the authors show that noise decreases during normal aging, and provide support for aging-associated increases in chromatin
Ping Liu +4 more
doaj +1 more source
An efficient multiplex approach to CRISPR/Cas9 gene editing in citrus
Plant MethodsCRISPR/Cas9-mediated gene editing requires high efficiency to be routinely implemented, especially in species which are laborious and slow to transform. This requirement intensifies further when targeting multiple genes simultaneously, which is required ...
Cintia H. D. Sagawa +6 more
doaj +1 more source
Spatial self-organization resolves conflicts between individuality and collective migration
Nature Communications, 2018 How bacteria migrate collectively despite individual phenotypic variation is not understood. Here, the authors show that cells spontaneously sort themselves within moving bands such that variations in individual tumble bias, a determinant of gradient ...
X. Fu +7 more
doaj +1 more source
Communications Biology, 2022 The current state and limitations of research on extracellular vesicles in central nervous system (CNS) signaling are discussed, with particular focus on EV-mediated cargo transfer.
Chun Wan +2 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
wiley +1 more source
The Philosophy of Molecular and Developmental Biology [PDF]
, 2000 Philosophical discussion of molecular and developmental biology began in the late 1960s with the use of genetics as a test case for models of theory reduction.
Griffiths, Paul Edmund
core
Self-repair ability of evolved self-assembling systems in cellular automata [PDF]
, 2014 Self-repairing systems are those that are able to reconfigure themselves following disruptions to bring them back into a defined normal state. In this paper we explore the self-repair ability of some cellular automata-like systems, which differ from ...
Johnson, Colin G., Öztürkeri, Can
core +1 more source