Results 11 to 20 of about 344,481 (219)
Nature Communications, 2021 Learning-activated engram neurons play a critical role in memory recall but the role of these neurons in offline memory consolidation is unclear. The authors show that sleep-associated reactivation of learning-activated sensory neurons is necessary for ...
Brittany C. Clawson +13 more
doaj +1 more source
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway
Nature Communications, 2022 Lysosomal biogenesis errors often result in diseases including mucolipidosis. Here Zhang and Yang et al. identify TMEM251/GCAF as a mannose-6-phosphate modification regulator that is necessary for correct lysosomal targeting, and classify Mucolipidosis ...
Weichao Zhang +14 more
doaj +1 more source
Whole body regeneration and developmental competition in two botryllid ascidians
EvoDevo, 2021 Background Botryllid ascidians are a group of marine invertebrate chordates that are colonial and grow by repeated rounds of asexual reproduction to form a colony of individual bodies, called zooids, linked by a common vascular network.
Shane Nourizadeh +4 more
doaj +1 more source
Enhanced germline stem cell longevity in Drosophila diapause
Nature Communications, 2022 Drosophila enter adult reproductive diapause in low temperatures and short day, halting ovarian development yet preserving fertility. Here the authors show that ovarian arrest in diapause is distinct from other stress responses and that despite DNA ...
Sreesankar Easwaran +3 more
doaj +1 more source
Cell surface-localized CsgF condensate is a gatekeeper in bacterial curli subunit secretion
Nature Communications, 2023 Curli are functional amyloids present on the outer membrane of E. coli. CsgF is required for the proper assembly of curli. Here, we found that the CsgF phase separates in vitro and that the ability of CsgF variants to phase-separate is tightly correlated
Hema M. Swasthi +4 more
doaj +1 more source
Disease Models & Mechanisms, 2022 Nucleoporin 98KD (Nup98) is a promiscuous translocation partner in hematological malignancies. Most disease models of Nup98 translocations involve ectopic expression of the fusion protein under study, leaving the endogenous Nup98 loci unperturbed ...
Ajai J. Pulianmackal +6 more
doaj +1 more source
Nature Communications, 2019 The daily accumulation of the ZEITLUPE (ZTL) photoreceptor/E3 ubiquitin ligase relies on a light-dependent interaction with GIGANTEA (GI). Here the authors show that GI recruits two deubiquitylases to help stabilize the ZTL-GI complex during the day and ...
Chin-Mei Lee +5 more
doaj +1 more source
Lithium-sensing riboswitch classes regulate expression of bacterial cation transporter genes
Scientific Reports, 2022 Lithium is rare in Earth’s crust compared to the biologically relevant alkali metal cations sodium and potassium but can accumulate to toxic levels in some environments.
Neil White +4 more
doaj +1 more source
Nature Communications, 2017 Multiple mechanisms regulate Wnt/ß-catenin signalling. Zhanget al. describe a novel regulatory pathway and show that the activator of canonical Wnt signalling, Norrin, triggers endocytosis of its receptor Frizzled4 by promoting Frizzled4 ubiquitination.
Chi Zhang +5 more
doaj +1 more source
Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii
eLife, 2022 The agricultural pest Drosophila suzukii differs from most other Drosophila species in that it lays eggs in ripe, rather than overripe, fruit. Previously, we showed that changes in bitter taste sensation accompanied this adaptation (Dweck et al., 2021 ...
Wanyue Wang +5 more
doaj +1 more source