Results 111 to 120 of about 359,726 (298)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth [PDF]

, 2011
Tumors and associated stroma manifest mechanical properties that promote cancer. Mechanosensation of tissue stiffness activates the Rho/ROCK pathway to increase actomyosin-mediated cellular tension to re-establish force equilibrium.
Strachan, D., June Munro, Weaver, Valerie M, Samuel, M., Strachan, David, Weaver, V., Lopez, Jose I., Lopez, J.I., McGhee, Ewan J, Barker, N., Anderson, Kurt I, Schröder, E., Samuel, Michael S, McGhee, E., Nick Barker, McGhee, E.J., Ewan J. McGhee, Sansom, O.J., Brunton, Valerie G., Barker, Nick, Jose I. Lopez, Samuel, Michael S., Timpson, P., Brunton, V., Olson, Michael F, Munro, June, Sansom, Owen J., Croft, D.R., McGhee, Ewan J., Schröder, Ewald, Michael F. Olson, Valerie M. Weaver, Weaver, Valerie M., Ewald Schröder, Daniel R. Croft, Jing Zhou, Sansom, Owen J, Croft, Daniel R., Clevers, Hans, Brunton, Valerie G, Weaver, V.M., Hans Clevers, Olson, M.F., Paul Timpson, David Strachan, Samuel, M.S., Anderson, K.I., Lopez, Jose I, Owen J. Sansom, Anderson, Kurt I., Munro, J., Timpson, Paul, Clevers, H., Olson, Michael F., Croft, D., Lopez, J., Anderson, K., Zhou, J., Sansom, O., Brunton, V.G., Zhou, Jing, Olson, M., Croft, Daniel R, Kurt I. Anderson, Michael S. Samuel, Valerie G. Brunton   +65 more
core   +1 more source

Developmental phase transitions in Norway spruce [PDF]

, 2013
Plant development proceeds through distinct phases that are controlled by complex networks of regulatory genetic circuits and fine-tuned by environmental and endogenous cues.
Uddenberg, Daniel
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Developmental, Cellular and Molecular Biology of Benign Prostatic Hyperplasia [PDF]

Differentiation, 2011
William A, Ricke, Jill A, Macoska, Gerald R, Cunha   +2 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Frontiers in Cell and Developmental Biology, Genetics, Nutrition and Physiology

Lipidology is a specialty section of Frontiers in Cell and Developmental Biology, Frontiers in Genetics, Frontiers in Physiology and Frontiers in Nutrition.
RODRIGUEZ ESTRADA, MARIA TERESA
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Cellular automata and dynamical systems [PDF]

In this thesis we investigate the theoretical nature of the mathematical structures termed cellular automata. Chapter 1: Reviews the origin and history of cellular automata in order to place the current work into context.
Clewlow, Les
core