Results 31 to 40 of about 23,964 (265)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
On the Dynamical Behavior of Cellular Automata on Finite Groups
IEEE AccessDuring the last few decades, significant efforts have been devoted to analyze the dynamical behavior of cellular automata (CAs) on cyclic groups, their Cartesian power (referred to as linear cellular automata), and on general abelian groups (referred to ...
Alberto Dennunzio +2 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Early Warning Signals for Critical Transitions in Sandpile Cellular Automata
Frontiers in Physics, 2022 The sandpile cellular automata, despite the simplicity of their basic rules, are adequate mathematical models of real-world systems, primarily open nonlinear systems capable to self-organize into the critical state.
Andrey Dmitriev +4 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Asynchronous adaptive time step in quantitative cellular automata modeling
BMC Bioinformatics, 2004 Background The behaviors of cells in metazoans are context dependent, thus large-scale multi-cellular modeling is often necessary, for which cellular automata are natural candidates.
Sun Yan +3 more
doaj +1 more source
Cellular Automata are Generic [PDF]
Electronic Proceedings in Theoretical Computer Science, 2015 Any algorithm (in the sense of Gurevich's abstract-state-machine axiomatization of classical algorithms) operating over any arbitrary unordered domain can be simulated by a dynamic cellular automaton, that is, by a pattern-directed cellular automaton ...
Nachum Dershowitz, Evgenia Falkovich
doaj +1 more source
Pemodelan Evakuasi Pejalan Kaki di Ruang Koridor dengan Cellular Automata Studi Kasus Gempa Bumi
Techno.Com, 2022 Pemodelan Sistem Evakuasi Pejalan Kaki adalah sebuah sistem pemodelan untuk memodelkan pergerakan objek manusia untuk memberikan analisis pada kejadian evakuasi dalam studi kasus bencana Gempa Bumi.
Muarifin Muarifin +2 more
doaj +1 more source