Results 71 to 80 of about 2,435,187 (246)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Design of Cellular Manufacturing using Mathematical Programming: a comparative study with simulation modelling [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2013
Machine-part family formation is one of major applications of group technology (GT). The machine cell formation problem in cellular manufacturing system (CMS) involves the decomposition of the manufacturing system into machine cells.
Hassan Farsijani, Mohsen Shafiei Nikabadi   +1 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Dome-Shape Auxetic Cellular Metamaterials: Manufacturing, Modeling, and Testing

Frontiers in Materials, 2019
We present in this work the manufacturing, modeling, and testing of dome-shaped cellular structures with auxetic (negative Poisson's ratio) behavior.
Nathanael Easey, Dmytro Chuprynyuk, W. M. Syazwan Wan Musa, Angus Bangs, Yousef Dobah, Yousef Dobah, Anton Shterenlikht, Fabrizio Scarpa   +7 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Manufacturing Informatics Framework for Manufacturing Sustainability Assessment. In : Re-engineering Manufacturing for Sustainability, Springer [PDF]

, 2013
Manufacturing firms that wish to improve their environmental performance of their product, process, and systems are faced with a complex task because manufacturing systems are very complex and they come in many forms and life expectancies.
ZHAO, Yaoyao Fiona, ANDRIANKAJA, Héry, PERRY, Nicolas   +2 more
core  

Study and Implementation of Lean Manufacturing in a Garment Manufacturing Company: Bangladesh Perspective [PDF]

Journal of Optimization in Industrial Engineering, 2011
Lean manufacturing is a systematic approach to identifying and eliminating wastes (non-value added activities) through continuous improvement by conveying the product at the pull of the customer in pursuit of production.
Ripon Kumar Chakrabortty, Sanjoy Kumar Paul   +1 more
doaj  

A new method for minimizing cell underutilization in the process of dynamic cell forming and scheduling using artificial neural networks

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2019
Cell-load variation is considered as a major shortcoming in cellular manufacturing systems. It can cause long queues in front of machines and impose extra costs to the cellular layouts.
Aidin DELGOSHAEI, Chandima GOMES
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Identifications of part families and bottleneck parts in celluar manufacturing [PDF]

مطالعات مدیریت بهبود و تحول, 2004
Group technology (GT) has emerged as an important scientific philosophy in improving the productivity of manufacturing systems. GT philosophy offers a systems approach to the reorganization of traditional complex job shop and flow shop  manufacturing ...
abolfazl kazazi, seyed ali marashi
doaj