Results 71 to 80 of about 4,958,442 (285)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Fixed Point and Asymptotic Analysis of Cellular Neural Networks
Journal of Applied Mathematics, 2012 We firstly employ the fixed point theory to study the stability of cellular neural networks without delays and with time-varying delays. Some novel and concise sufficient conditions are given to ensure the existence and uniqueness of solution and the ...
Xianghong Lai, Yutian Zhang
doaj +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Asymptotic stability of time-varying delay-difference system of cellular neural networks via matrix inequalities and application [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2010 In this paper, we obtain some criteria for determining the asymptotic stability of the zero solution of time-varyingdelay-difference system of cellular neural networks in terms of certain matrix inequalities by using a discrete version of the Lyapunov ...
Kreangkri Ratchagit
doaj
Electronic Journal of Qualitative Theory of Differential Equations, 2018 In this paper we study a periodic impulsive Hopfield-type neural network system with piecewise constant argument of generalized type. Under general conditions, existence and uniqueness of solutions of such systems are established using ergodicity, Green ...
Manuel Pinto +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Extended LaSalle’s invariance principle for full-range cellular neural networks
, 2008 The paper develops a Lyapunov method, which is based on a generalized version of LaSalle's invariance principle, for studying convergence and stability of the differential inclusions modeling the dynamics of the full-range (FR) model of cellular neural ...
DI MARCO M. +7 more
core +1 more source