Results 141 to 150 of about 3,960,239 (293)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Photograph - Activities Office staff
, 2019 This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete.
University Of Melbourne. Media And Publication Services Office
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
A Civilian Defense Volunteer Office
, 1941 Pamphlet about civilian defense volunteer offices in the United States during World War II. The pamphlet includes information on the purpose and functions of a civilian defense volunteer office, how to set one up and organize it, and what the office does.
United States. Office of Civilian Defense
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Office of Public Guardian annual report
, 2016 The Northern Territory Office of the Public Guardian commenced operations as an independent statutory authority on 28 July 2016, with the introduction of the Guardianship of Adults Act 2016.Made available by the Northern Territory Library via the ...
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News from the Office of Research
, 2019 February 2019: National Institutes of Health (NIH) Reminder of Policy Changes for proposals -- URCA due April 5 -- Higuchi - KU Endowment Research Achievement Awards -- New policy regarding use of UAS on campus -- WSU team creates device that will aid in
Office of Research
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Hospital Planning Office Guidelines: Health Board Subject Teams
, 1976 This document to be read in conjunction with the Hospital Planning Office Guidelines - The Health Board as Building Client (Hospital, Planning Office 1) and Expenditure on Capital projec,ts by Health Boards (Hospital Planning Office 2).
Health Boards +2 more
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source