Results 141 to 150 of about 123,953 (269)

Metabolic‐Immune Suppression Mediated by the SIRT1‐CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma

Advanced Science, EarlyView.
This study discovers that SIRT1, a hub gene involved in glucolipid metabolic conversion in colorectal carcinoma (CRC), stimulates CX3CL1 secretion in CRC cells by activating FOXO1. The CX3CL1‐CX3CR1 signaling promotes the differentiation of TCF7+ regulatory T cells (Tregs) into an enhanced immunosuppressive TNFRSF9+ Treg phenotype.
Ruiyang Zi, Xiang Zhao, Limei Liu, Yijie Wang, Rui Zhang, Zhiheng Bian, Haoran Jiang, Taorui Liu, Yixin Sun, Han Peng, Xuesong Wang, Fanghao Lu, Chao Zhang, Fan Zhang, Qing Qin, Houjie Liang, Jianjun Li, Zhihao Wei, Yan Dong   +18 more
wiley   +1 more source

Copy number variations in healthy subjects. Case study: iPSC line CSSi005-A (3544) production from an individual with variation in 15q13.3 chromosome duplicating gene CHRNA7

Stem Cell Research, 2018
CHRNA7, encoding the neuronal alpha7 nicotinic acetylcholine receptor (a7nAChR), is highly expressed in the brain, particularly in the hippocampus. It is situated in the 15q13.3 chromosome region, frequently associated with a Copy Number Variation (CNV),
Elisa Maria Turco, Ersilia Vinci, Filomena Altieri, Daniela Ferrari, Barbara Torres, Marina Goldoni, Giuseppe Lamorte, Ada Maria Tata, Gianluigi Mazzoccoli, Diana Postorivo, Matteo Della Monica, Laura Bernardini, Angelo Luigi Vescovi, Jessica Rosati   +13 more
doaj  

Editorial: Cellular reprogramming in development, disease, and design of cell-replacement therapies. [PDF]

Front Cell Dev Biol, 2023
Burke ZD, Lyon C, Perán M.
europepmc   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature. [PDF]

Sci Rep, 2023
Horisawa K, Miura S, Araki H, Miura F, Ito T, Suzuki A.   +5 more
europepmc   +1 more source

Deciphering the Transcription Factor Landscape in Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation

Advanced Science, EarlyView.
The study deciphers the landscapes of lineage‐related transcription factors in prostatic adenocarcinoma and neuroendocrine prostate cancer using an innovative approach. These findings, validated across cohorts, highlight TFs' roles in cell development and offer novel therapeutic targets.
Yu Wang, Hui Xue, Xiaohui Zhu, Dong Lin, Zheng Chen, Xin Dong, Junru Chen, Mingchen Shi, Yuchao Ni, Jonathan Cao, Rebecca Wu, Connie Kang, Xinyao Pang, Francesco Crea, Yen‐Yi Lin, Colin C. Collins, Martin E. Gleave, Abhijit Parolia, Arul Chinnaiyan, Christopher J. Ong, Yuzhuo Wang   +20 more
wiley   +1 more source

Generation of an induced pluripotent stem cell line, CSSi011-A (6534), from an Amyotrophic lateral sclerosis patient with heterozygous L145F mutation in SOD1 gene

Stem Cell Research, 2020
Among the known causative genes of familial ALS, SOD1 mutation is one of the most common. It encodes for the ubiquitous detoxifying copper/zinc binding SOD1 enzyme, whose mutations selectively cause motor neuron death, although the mechanisms are not as ...
Angela D'Anzi, Filomena Altieri, Elisa Perciballi, Daniela Ferrari, Laura Bernardini, Marina Goldoni, Letizia Mazzini, Fabiola De Marchi, Alice Di Pierro, Sandra D'Alfonso, Maurizio Gelati, Angelo Luigi Vescovi, Jessica Rosati   +12 more
doaj  

Cyclic Stretch Promotes Cellular Reprogramming Process through Cytoskeletal-Nuclear Mechano-Coupling and Epigenetic Modification. [PDF]

Adv Sci (Weinh), 2023
Park SM, Lee JH, Ahn KS, Shim HW, Yoon JY, Hyun J, Lee JH, Jang S, Yoo KH, Jang YK, Kim TJ, Kim HK, Lee MR, Jang JH, Shim H, Kim HW.   +15 more
europepmc   +1 more source

CCL20/CXCL5 Drives Crosstalk Between Anaplastic Thyroid Cancer Stem Cells and Tumor‐Associated Macrophages to Promote Tumor Progression

Advanced Science, EarlyView.
This study elucidates the crosstalk between tumor‐associated macrophages (TAMs) and anaplastic thyroid cancer stem cells (ATCSCs). The findings reveal that CCL20 from THP‐1‐M2 activates the IRAK‐1/NF‐κB1/2 pathway in ATCSCs, thereby enhancing CXCL5 secretion.
Qi Liu, Yan Wang, Mingyuan Song, Jiapeng Huang, Jinyuan Shi, Wei Sun, Xiaoyu Ji, Yuang Chang, Bing Ma, Ping Zhang, Yuanyuan Yan, Hao Zhang   +11 more
wiley   +1 more source

Senescence-induced cellular reprogramming drives cnidarian whole-body regeneration. [PDF]

Cell Rep, 2023
Salinas-Saavedra M, Febrimarsa, Krasovec G, Horkan HR, Baxevanis AD, Frank U.   +5 more
europepmc   +1 more source