Results 141 to 150 of about 224,348 (348)
Advanced Functional Materials, EarlyView.A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria +7 more
wiley +1 more source
In vivo reprogramming: A new approach for tissue repair in chronic diseases
Chronic Diseases Journal, 2017 Medical researchers and biologists have long been fascinated by the possibility of changing the identity of cells, a phenomenon known as cellular plasticity.
Saman Esmaeilnejad +3 more
doaj +1 more source
Advanced Functional Materials, EarlyView.This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv +10 more
wiley +1 more source
Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy
Advanced Functional Materials, EarlyView.FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao +8 more
wiley +1 more source
Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding
Nature CommunicationsOverexpression of the transmembrane matrix metalloproteinase MT1-MMP/MMP14 promotes cancer cell invasion. Here we show that MT1-MMP-positive cancer cells turn MT1-MMP-negative cells invasive by transferring a soluble catalytic ectodomain of MT1-MMP ...
Eva Maria Wenzel +9 more
doaj +1 more source
Context-Dependent Impact of RAS Oncogene Expression on Cellular Reprogramming to Pluripotency
Stem Cell Reports, 2019 Summary: Induction of pluripotency in somatic cells with defined genetic factors has been successfully used to investigate the mechanisms of disease initiation and progression.
Alba Ferreirós +12 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava +7 more
wiley +1 more source
Advances in Liquid Biopsy for Diagnosis of Bladder Cancer [PDF]
International Neurourology JournalBladder cancer (BCa) is the most common malignancy of the urinary system. It has a high recurrence rate and requires longterm follow-up. Significant advances in BCa research have been made in recent years; however, the initial diagnosis and follow-up of ...
Jaekwon Seok +4 more
doaj +1 more source
Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis [PDF]
, 2015 Bo-Hua Jiang +6 more
openalex +1 more source
Microneedle‐Based Biofertilizer Delivery Improves Plant Growth Through Microbiome Engineering
Advanced Functional Materials, EarlyView.This figure shows how microneedles are used to deliver biofertilizers to enhance plant growth through microbial migration, metabolic reprogramming, and changes in plant endogenous microbiome. Abstract This study presents a microneedle‐based system for the delivery of rhizospheric biofertilizers into plant tissues to enhance growth.
Zhicheng Le +14 more
wiley +1 more source