Results 211 to 220 of about 1,011,776 (290)

Hijacking the Electron Train: Menaquinone‐Binding Antimicrobial Peptides

open access: yesChemBioChem, EarlyView.
Menaquinone is an emerging target for antimicrobial peptides. Could it be the new Achilles’ Heel of bacteria? The rise of antibiotic resistance threatens to undermine modern medicine, making the development of new antibiotics and novel targets an urgent priority.
Eilidh J. Matheson, Stephen A. Cochrane
wiley   +1 more source

Tislelizumab: Structural Innovations and Expanding Clinical Horizons in Next‐Generation PD‐1 Immunotherapy

open access: yesChronic Diseases and Translational Medicine, EarlyView.
The interaction of tislelizumab with PD‐1/PD‐L1 in the tumor microenvironment. Tislelizumab targets PD‐1 on T cells, blocking its interaction with PD‐L1 on tumor cells. This action is facilitated by a modified F(ab) region that limits Fc‐γ receptor binding, thereby enhancing the antitumor immune response. ABSTRACT Tislelizumab is a next‐generation PD‐1
Thy T. Nguyen   +4 more
wiley   +1 more source

Activation of Allenes by Diferrocenylphosphenium Ion: Isolation of a Wheland Intermediate of Ferrocene

open access: yesChemistryEurope, EarlyView.
A kinetically stable Wheland intermediate of the electrophilic aromatic substitution at ferrocene is isolated from the reaction of the diferrocenylphosphenium ion with the allene 2‐(trimethylsilyl)‐2,3‐pentadiene and fully characterized. The reaction of the diferrocenylphosphenium ion with four terminal allenes follows two different pathways, via allyl
Corina Stoian   +7 more
wiley   +1 more source

Accurate and Rapid Ranking of Protein–Ligand Binding Affinities Using Density Matrix Fragmentation and Physics‐Informed Machine Learning Dispersion Potentials

open access: yesChemPhysChem, EarlyView.
Two efficient methods, generalized many‐body expansion for building density matrices (GMBE‐DM) and D3‐ML, are introduced for ranking protein–ligand binding affinities. GMBE‐DM delivers quantum‐accurate results within minutes, while D3‐ML achieves even higher accuracy in under one second per complex.
Ka Un Lao, Danyang Wang
wiley   +1 more source

Salt‐Induced Modulation of Self‐Assembly in C8‐10 AlkylPolyGlucoside/Fatty Alcohol Formulations

open access: yesChemPlusChem, EarlyView.
Salt's effect on the APG:1‐Dodecanol system was studied. Small‐angle X‐ray scattering showed salt increased interparticle correlation, leading to higher structural organization at higher salt concentrations. This correlates with observed viscoelastic properties. Cleaning efficiency tests were also conducted on samples.
Lorenzo Veronico, Luigi Gentile
wiley   +1 more source

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