Results 191 to 200 of about 221,966 (358)

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang   +7 more
wiley   +1 more source

Environmental Sustainability and Business Profitability: Profiling Winners and Losers With Machine Learning

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT We utilize a rich dataset of manufacturing firms to investigate the heterogeneous effects of ISO 14001 on the financial performance of certified firms. We employ machine learning techniques, specifically causal tree and causal forest, to uncover these effects. Our findings reveal consistently positive average effects of ISO 14001 certification
Xiaoliu Xu, Abdoul G. Sam
wiley   +1 more source

The Cement Spiral [PDF]

open access: yesJournal of Obstetrics and Gynaecology Canada, 2018
openaire   +4 more sources

Navigating Digital Servitization for the Twin Transition: How Manufacturers Can Support Customers With Digitalization and Sustainability

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT As industrial sustainability concerns mount, manufacturers engaged in digital servitization grapple with the twin transition of configuring and implementing digital solutions to meet their customers' sustainability objectives. To address this challenge, a socio‐technical systems theory‐based framework is proposed.
Taylan Kilinc   +2 more
wiley   +1 more source

Laterally positioned flap with connective tissue graft to treat deep isolated gingival recessions in the mandibular anterior region: A retrospective case series with 10‐year follow‐up

open access: yesClinical Advances in Periodontics, EarlyView.
ABSTRACT Background To evaluate the efficacy and long‐term clinical outcomes of the one‐stage procedure for covering isolated deep gingival recessions (GRs) in the mandibular anterior region employing a laterally positioned flap (LPF) with a connective tissue graft (CTG), with a retrospective case series.
Lucrezia Parma‐Benfenati   +1 more
wiley   +1 more source

Biomechanical Impact of Cementation Technique Variations on Femoral Stem Stability: An In Vitro Polyurethane Model Study. [PDF]

open access: yesJ Clin Med
Fazakas R   +9 more
europepmc   +1 more source

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