Results 91 to 100 of about 11,433 (246)

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Development of Dimensionless Parameters and Groups of Heat and Mass Transfer to Predict Wax Deposition in Crude Oil Pipelines

ACS Omega, 2021
Jatin R. Agarwal, Carlos F. Torres, Subhash Shah   +2 more
doaj   +1 more source

The influence of multi-scale tough liquid fiber toughening agent on the mechanical properties of oil well cement-based composite materials

Materials Research Express
Cementing is a key process in drilling engineering, and the cement sheath in cementing can sometime have problems such as significant brittleness, low toughness, and low resistance to impact damage, especially in perforation and fracturing environments ...
Qingshan Meng
doaj   +1 more source

Adhesive cements and cementation.

Journal of the California Dental Association, 1993
Luting cements are a critical, but weak, link between fixed prostheses and their supporting tooth structures. Luting cements have relatively poor physical properties compared to bulk restorative filling materials, but they must fulfill an additional series of requirements such as low film thickness.
openaire   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

Multimodal Layer‐Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes

Advanced Science, EarlyView.
The study introduces a flexible microfluidic axialtrode that integrates optical, electrical, and chemical modalities within a single polymer fiber. By redistributing electrodes and fluidic channels along the fiber axis via angled cleaving, it enables simultaneous optogenetic stimulation, electrophysiological recording, and drug delivery across brain ...
Kunyang Sui, Neela K. Codadu, Daman Rathore, Guanghui Li, Marcello Meneghetti, Anders L. Bøcker, Rune W. Berg, Rob C. Wykes, Christos Markos   +8 more
wiley   +1 more source

Ferroelectric‐Polarization‐Driven Structural Engineering of Bi3Nb17O47 Anodes for High‐Performance Lithium‐Ion Batteries

Advanced Science, EarlyView.
A transformative ferroelectric‐polarization strategy is employed to overcome the intrinsic limitations of tungsten bronze (TTB)‐type anode materials in metal‐ion batteries, using Bi3Nb17O47 as a model system. By exploiting the non‐centrosymmetric crystal structure and field‐induced ionic displacements, controlled structural engineering with ...
Xiaoming Lou, Songjie Li, Chunfu Lin, Yanchao Li, Mingze Sun, Zhen Liu, Weiye Nie, Xiaolong Tang, Baoming Wang, Wenwu Cao, Renchao Che   +10 more
wiley   +1 more source

A Cement Bond Quality Prediction Method Based on a Wide and Deep Neural Network Incorporating Embedded Domain Knowledge

Applied Sciences
Cement bond quality is critical to ensuring the long-term safety and structural integrity of oil and gas wells. However, due to the complex interdependencies among geological conditions, operational parameters, and fluid properties, accurately predicting
Rengguang Liu, Jiawei Yu, Luo Liu, Zheng Wang, Shiming Zhou, Zhaopeng Zhu   +5 more
doaj   +1 more source

Electrochemical Nitrate Reduction Reaction to Ammonia at Industrial‐Level Current Densities

Advanced Science, EarlyView.
This review starts from the mechanism and theoretical basis of electrochemical nitrate reduction reaction (NO3−RR), and systematically summarizes and discusses the design strategies of industrial‐level current density catalysts. In addition, the progress of industrial‐level NO3−RR‐based electrolyzers, including flow reactor and membrane electrode ...
Zhijie Cui, Honghai Wang, Chunli Li, Wenchao Peng, Jiapeng Liu   +4 more
wiley   +1 more source