Results 121 to 130 of about 158,226 (307)

Signaling Mutations Negate the Favorable Impact of NPM1 Mutations in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With VEN/HMA

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Frameshift mutations in exon 12 of nucleophosmin 1 (NPM1mut) are among the most common mutations in acute myeloid leukemia (AML) and have historically been considered favorable‐risk in the absence of FLT3‐ITD. In the European LeukemiaNet (ELN) 2024 risk‐classification for patients treated with hypomethylating agents plus venetoclax (HMA + VEN),
Fieke W. Hoff   +44 more
wiley   +1 more source

Quizartinib in Combination With FLAG‐IDA for Relapsed or Refractory Acute Myeloid Leukemia (FLAG‐QUIDA): A PETHEMA Phase I‐II Trial

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Quizartinib is a tyrosine kinase inhibitor with single agent activity in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) and has demonstrated efficacy in first‐line therapy when combined with intensive chemotherapy in both FLT3 ITD‐negative and positive AML.
Teresa Bernal   +29 more
wiley   +1 more source

A CENSORED SYSTEM ESTIMATION OF HISPANIC HOUSEHOLD FOOD CONSUMPTION PATTERNS [PDF]

open access: yes
A system of nine censored Engel curve equations was estimated for Hispanic households in the U.S.: grains, vegetables, fruits, milk, meat, legumes, fats, sugar, and beverages.
Huang, Chung L.   +2 more
core   +1 more source

Clinical Predictors of Response in Chronic Graft‐Versus‐Host Disease: Results From the “Predicting the Quality of Response to Specific Treatments (PQRST)” Trial

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Despite significant progress in chronic GVHD therapies, challenges remain in understanding pleomorphic phenotypes and varying responses to treatment. The aim of this study was to identify predictors of treatment response. We conducted a prospective, observational cohort study of patients beginning first‐, second‐, or third‐line systemic ...
Betty K. Hamilton   +11 more
wiley   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

open access: yesCancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada   +16 more
wiley   +1 more source

Inferring the Timing of Antiretroviral Therapy by Zero-Inflated Random Change Point Models Using Longitudinal Data Subject to Left-Censoring

open access: yesAlgorithms
We propose a new random change point model that utilizes routinely recorded individual-level HIV viral load data to estimate the timing of antiretroviral therapy (ART) initiation in people living with HIV.
Hongbin Zhang   +6 more
doaj   +1 more source

Multiple imputation of right-censored wages in the German IAB Employment Sample considering heteroscedasticity [PDF]

open access: yes
"In many large data sets of economic interest, some variables, as wages, are top-coded or right-censored. In order to analyze wages with the German IAB employment sample we first have to solve the problem of censored wages at the upper limit of the ...
Büttner, Thomas, Rässler, Susanne
core  

Clinical Outcomes and Patient Experiences With Celiprolol Therapy in Vascular Ehlers–Danlos Syndrome: The First Non‐European Cohort

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Vascular Ehlers–Danlos syndrome (vEDS) is a hereditary connective tissue disorder caused by heterozygous pathogenic variants in COL3A1. European studies have shown that celiprolol may reduce the risk of life‐threatening vascular events, but outcomes in non‐European populations and the therapy's psychological impact remain unclear. We conducted
Megumi Furuhata‐Yoshimura   +2 more
wiley   +1 more source

Heavy Metal Concentrations in Particulate Matter: A Case Study from Santo Domingo, Dominican Republic, 2022

open access: yesAtmosphere
This study assessed the concentrations and spatial patterns of heavy metals in fine particulate matter with aerodynamic diameter below 2.5 μm and coarse particulate matter with aerodynamic diameter below 10 μm in Santo Domingo, Dominican Republic, during
Carime Matos-Espinosa   +4 more
doaj   +1 more source

Techniques for estimating health care costs with censored data: an overview for the health services researcher [PDF]

open access: yes, 2012
Harindra C Wijeysundera,1–5 Xuesong Wang,5 George Tomlinson,2,4 Dennis T Ko,1,3–5 Murray D Krahn,2–4,61Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University ...
Wijeysundera HC   +4 more
core  

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