Results 101 to 110 of about 21,026 (285)
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Le groupe interdisciplinaire de doctorants moniteurs de l’Université d’Aix-Marseille organise, le 18, 19 et 20 novembre 2008 à la Maison Méditerranéenne des sciences de l’homme d’Aix-en-Provence, un colloque autour du thème de la censure à l’époque contemporaine.
openaire +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
De la censure théâtrale à la censure cinématographique
La censure reprenant son ancienne besigne, par Cham (1852), Bibliothèque de Bordeaux. 12 décembre 2013 par Patrick Désile (CNRS) Bibliographie - Odile Krakovitch, Censure des répertoires des grands théâtres parisiens (1835-1906 ...
Nicolas Schmidt
core
Fondement psycho-politique de la censure
Valabrega Jean-Paul. Fondement psycho-politique de la censure. In: Communications, 9, 1967. La censure et le censurable. pp.
Valabrega, Jean-Paul
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Un’altra visione delle cose: note sulla satira nel Risorgimento
The paper draws a historical portrait of literary satire in Italy from 1830 up to the achievement of Italian unification. Through four paragraphs, I will discuss Carlo Bini’s gloomy reinterpretation of Sterne’s style; Giacomo Leopardi’s Neapolitan ...
Marco Viscardi (1978) si è addottorato in Filologia Moderna nel 2009 (Università degli Studi di Napoli “Federico II”) discutendo una tesi sulle lezioni dantesche di F. A. Ozanam (1813-1852); attualmente borsista presso l’Istituto Italiano per gli Studi Storici, lavora ad una monografia su satira ed umorismo in Italia fra 1816 e 1861. Cultore della materia presso le cattedre di Storia della Critica Letteraria e Letteratura Italiana II, titolare il prof. Giovanni Maffei, si è occupato di romanzo storico fra Otto e Novecento e di storiografia letteraria, e ha pubblicato interventi su Tomasi di Lampedusa, Manganelli e Giuseppe Giusti.
doaj
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source

