Results 101 to 110 of about 134,263 (296)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Un’altra visione delle cose: note sulla satira nel Risorgimento
Diacronie. Studi di Storia Contemporanea, 2012 The paper draws a historical portrait of literary satire in Italy from 1830 up to the achievement of Italian unification. Through four paragraphs, I will discuss Carlo Bini’s gloomy reinterpretation of Sterne’s style; Giacomo Leopardi’s Neapolitan ...
Marco Viscardi (1978) si è addottorato in Filologia Moderna nel 2009 (Università degli Studi di Napoli “Federico II”) discutendo una tesi sulle lezioni dantesche di F. A. Ozanam (1813-1852); attualmente borsista presso l’Istituto Italiano per gli Studi Storici, lavora ad una monografia su satira ed umorismo in Italia fra 1816 e 1861. Cultore della materia presso le cattedre di Storia della Critica Letteraria e Letteratura Italiana II, titolare il prof. Giovanni Maffei, si è occupato di romanzo storico fra Otto e Novecento e di storiografia letteraria, e ha pubblicato interventi su Tomasi di Lampedusa, Manganelli e Giuseppe Giusti.
doaj
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
La lettre comme moyen de dénonciation : étude de « Pour la liberté de pensée »de Voltaire
Revista de Lenguas Modernas, 2010 Dans l’une de ces nombreuses lettres intitulée Pour la liberté de pensée nous étudierons les raisons pour lesquelles Voltaire considère qu’il ne faut pas interdire les livres. Pour ce faire, nous analyserons les outils linguistiques utilisés par l’auteur
Beatriz Rodríguez Oconitrillo
doaj
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Should impact constitute mitigation?: structured discretion versus mercy [PDF]
, 2007 Sentencing guidance on the weight to be given to mitigation about the impact of punishment on an offender has differentiated between serious and less serious offending and between degrees and types of disadvantage. This article reviews current sentencing
Piper, CD
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Censure littéraire et circulation des imprimés entre le Portugal et le Brésil (1769–1821) [PDF]
, 2016 Luiz Carlos Villalta
openalex +1 more source
Paying Attention to Cernuda and Bergamin Literary Surveillance during Francoism [PDF]
, 2017 El ensayo literario es un género que no se destina a un público amplio si lo comparamos con los dirigidos a lectores de novelas o de poemas. Sin embargo, parece que la censura franquista no consideraba dicha diferencia, ya que actuó con igual ...
Marco, Valeria de
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Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source