Results 141 to 150 of about 21,036 (287)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Censur!

Recension av Jon Helgason: Censur på gott och ont. Riksbankens jubileumsfond / Makadam förlag 2025.
openaire   +1 more source

Characterization of cases and analysis of First-instance Judgments in Ethical Proceedings at the Regional Council of Veterinary Medicine of the State of São Paulo. [PDF]

Braz J Vet Med
Ruiz RT, Bosch RV, Stringari S, Ruiz JLM, Maiorka PC.   +4 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Opening the black box of the Spanish legislative Process: The Legislative Amendments Dataset (1996-2023). [PDF]

Data Brief
Palau AM, Casas A, Muñoz L, Rodilla A.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

La censure militaire et policière, 1914-1918

, 2014
RAJSFUS Maurice La censure militaire et policière, 1914-1918 Paris : Le Cherche midi, 2014, 327 p. Collection Documents ISBN 978-2-7491-3575-5 FR 1681 Résumé éditeur : Dès les premiers jours de la Grande Guerre, la censure est instaurée et cette mesure ...
Nordoc'Archéo
core  

Punishing to Send a Message ^†. [PDF]

Oxf J Leg Stud
Ryu A, Sewell T.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Real-world experience with Janus kinase inhibitors in rheumatoid and psoriatic arthritis: retention and discontinuation factors in a UK six-centre cohort. [PDF]

Rheumatol Adv Pract
Nathan J, Farisogullari B, Jones N, Ayoub M, Brown J, Levy S, Brader J, Ersoy A, Israni B, Lloyd M, Latheef A, Hill D, Taylor A, Arachchige D, Chitsu H, Linklater H, Lather K, Gompels L, Elfar E, Malaiya R, Machado PM, Kiely PDW.   +21 more
europepmc   +1 more source