Results 81 to 90 of about 6,693 (256)
Censure: Moral and Sociological [PDF]
, 2017 The concept of censure, as developed in different ways, in the work of Sumner and von Hirsch, has enormous potential—though each of the accounts has its own limitations—In this chapter, I discuss both theories and show some way in which there is a common ground between them, and to offer some suggestions as to ways that this common ground might be ...
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
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Calenda, 2007 Le groupe interdisciplinaire de doctorants moniteurs de l’Université d’Aix-Marseille organise, le 18, 19 et 20 novembre 2008 à la Maison Méditerranéenne des sciences de l’homme d’Aix-en-Provence, un colloque autour du thème de la censure à l’époque contemporaine.
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Un’altra visione delle cose: note sulla satira nel Risorgimento
Diacronie. Studi di Storia Contemporanea, 2012 The paper draws a historical portrait of literary satire in Italy from 1830 up to the achievement of Italian unification. Through four paragraphs, I will discuss Carlo Bini’s gloomy reinterpretation of Sterne’s style; Giacomo Leopardi’s Neapolitan ...
Marco Viscardi (1978) si è addottorato in Filologia Moderna nel 2009 (Università degli Studi di Napoli “Federico II”) discutendo una tesi sulle lezioni dantesche di F. A. Ozanam (1813-1852); attualmente borsista presso l’Istituto Italiano per gli Studi Storici, lavora ad una monografia su satira ed umorismo in Italia fra 1816 e 1861. Cultore della materia presso le cattedre di Storia della Critica Letteraria e Letteratura Italiana II, titolare il prof. Giovanni Maffei, si è occupato di romanzo storico fra Otto e Novecento e di storiografia letteraria, e ha pubblicato interventi su Tomasi di Lampedusa, Manganelli e Giuseppe Giusti.
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
La lettre comme moyen de dénonciation : étude de « Pour la liberté de pensée »de Voltaire
Revista de Lenguas Modernas, 2010 Dans l’une de ces nombreuses lettres intitulée Pour la liberté de pensée nous étudierons les raisons pour lesquelles Voltaire considère qu’il ne faut pas interdire les livres. Pour ce faire, nous analyserons les outils linguistiques utilisés par l’auteur
Beatriz Rodríguez Oconitrillo
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