Results 91 to 100 of about 2,076,711 (304)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Keanu: a novel visualization tool to explore biodiversity in metagenomes

BMC Bioinformatics, 2019
Background One of the main challenges when analyzing complex metagenomics data is the fact that large amounts of information need to be presented in a comprehensive and easy-to-navigate way.
Adam Thrash, Mark Arick, Robyn A. Barbato, Robert M. Jones, Thomas A. Douglas, Julie Esdale, Edward J. Perkins, Natàlia Garcia-Reyero   +7 more
doaj   +1 more source

Illustration of the segmented regions of the corpus callosum fiber tract overlaid on the FA map.

, 2014
For each subject, the CC is segmented into three regions manually: left, right, and center. Our proposed model is applied to these regions and only the center part is used for validating the model using histological data.
Michael Chopp (95019), Hamid Soltanian-Zadeh (187393), Quan Jiang (187398), Shiyang Wang (517692), Esmaeil Davoodi-Bojd (565284), Guangliang Ding (470922)   +5 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Agronomic Performance and Stability of Vegetable Amaranth (Amaranthus spp.) Genotypes in Benin

Plant-Environment Interactions
Amaranth is a vegetable and grain crop with the potential to contribute to nutrition security and income generation. However, amaranth production in Benin faces several constraints, including the limited availability of improved varieties and access to ...
Mathieu A. T. Ayenan, Lys A. Aglinglo, Lydi C. Amoussou, Roland M. Sossa, Chedrac Zokpon, Fekadu Fufa Dinssa, Roland Schafleitner   +6 more
doaj   +1 more source

The Diversity of cereal pests (wheat and barley) grown in arid climate in Ziban region (provence of Biskra- southeastern Algeria)

Studia Universitatis Babeș-Bolyai. Biologia
This study investigated cereal pests (wheat and barley) grown in southeastern Algeria's arid climate. Using three sampling techniques (yellow pan traps and Pitfall traps, a comprehensive collection of insect specimens was obtained, comprising 2526 ...
Nourelhouda Bakroune, Abdelmoneim Tarek Ouamane, Meriem Boultif, Farida Bettiche, Somia Torki Torki   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Antimicrobial resistance varies with warming in active layer soil and permafrost

Scientific Reports
Although antimicrobial resistance is a contemporary public health concern, antimicrobial resistance genes (ARGs) have existed long before human use of antimicrobials, and recent attention has focused on whether permafrost thaw could release ARGs as the ...
Quincy Faber, Christopher C. M. Baker, Jaimie R. West, Stacey J. Doherty, Jessica G. Ernakovich, Robyn A. Barbato   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Drivers of change in Benin’s vegetable food system

Cogent Food & Agriculture
Most food systems are far from perfect, and in aggregate are operating outside of safe boundaries in terms of diets, livelihoods and environment. This study uses narrative synthesis across multiple studies and data sources, aiming to determine which food
Edmond Totin, Mathieu A. T. Ayenan, Djibril Aboubakar Souna, Christelle M. Komlan Ahihou, Nestor Alokpai, Nadia Fanou Fogny, Bart de Steenhuijsen Piters, Jody Harris   +7 more
doaj   +1 more source