Results 171 to 180 of about 2,076,711 (304)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Depression: higher temporal variability of the functional connectivity of the ventromedial prefrontal cortex and hippocampal system. [PDF]

Neuroimage Clin
Chen Y, Rolls ET, Yu Y, Huang CC, Luo Q, Cheng W, Wang X, Zhang T, Feng J.   +8 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Regional Enhancement Center [PDF]

, 2020
openaire   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Byrd Polar Research Center

The Byrd Polar Research Center undertakes research programs in polar and alpine research, focusing on the role of cold regions in the global climate ...

core   +1 more source

Brain distortion and cerebrospinal fluid shifts in spontaneous intracranial hypotension. [PDF]

Fluids Barriers CNS
El Rahal A, Beck J, Wolf K, Volz F, Overstijns M, Lützen N, Zander C, Urbach H, Scheffler P.   +8 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Expert Consensus on the Standardized Diagnosis, Treatment, and Management of Cancer in High-Altitude Regions of China. [PDF]

Cancer Innov
Li Y, Li F, Bai X, Li Y, Bai C, Chang Q, Guo C, Di J, Dong Q, Da M, Li Z, Liu Z, Liang H, Luo Y, Ren D, Yu P, Ma R, Wang M, Zhao X, Zhao F, Shen G, Feng Z, Wang H, Zhou S, Wei W, Chen S, Wang L, Du F, Tseyang, Xu H, Ling X, Xu G, Guo W, Zhao Y, Sang D, Feng H, Deqingwangmu, Gesangdeji, Basangdunzhu, Bianbazhaxi, Guo Y, Tao X, Bai G, Yang W, Luo H, Lei Y, Cidanwangjiu, Ma F, Wu D, Zhao J.   +49 more
europepmc   +1 more source