Results 201 to 210 of about 2,076,711 (304)

Suicide mortality in Kazakhstan from 2012 to 2024: temporal trends, demographic inequalities, and regional variation. [PDF]

Front Public Health
Kossumov A, Zhakupova T, Imambayeva N, Polyakova T, Dalibayeva G, Syzdykova B, Kovenskiy A, Rakhmankulova A, Vinogradova E, Kalmakhanov S, Kozhakhmetov S, Kushugulova A.   +11 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

A New Approach to Postexposure Treatment of Rabies by Complex of Immuno-and Chemotherapy in Belarus

Антибиотики и Химиотерапия, 2020
N. P. Mishayeva, V. I. Votyakov, L. P. Titov, V. A. Naralenkov, M. R. Nekhay, V. V. Sinkevich, A. I. Kurlukov, V. A. Gorbunov   +7 more
doaj  

Correction: Genetic differentiation of Oncomelania hupensis robertsoni in hilly regions of China: Using the complete mitochondrial genome. [PDF]

PLoS Negl Trop Dis
Song J, Wang H, Li S, Qian P, Wang W, Shen M, Zhang Z, Zhou J, Li C, Yang Z, Hao Y, Du C, Dong Y.   +12 more
europepmc   +1 more source

CENTERS OF REGIONS VS. REGIONAL COHESION IN POLAND

Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2017
Krystian Heffner, Piotr Gibas
openaire   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

An AI-powered self-driving microscope for low-cost acute leukemia detection. [PDF]

Nat Commun
Yan ES, Sun S, Yin Z, Kamali A, Van Cleave J, Isgor IS, Fried B, Colorado-Jimenez C, Dilip D, Baik J, Manzo A, Paulsen S, Singi S, Drapeau S, Eren OC, Chun JK, Syed A, Cardillo A, Pulitzer M, Fenelus M, Kim D, Benhamida J, Ng D, Ardon O, Roshal M, Dogan A, Vanderbilt C, Bilal KH, Goldgof GM.   +28 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Policies for employment centers in metropolitan regions

Proceedings of the Eastern Asia Society for Transportation Studies, 2007
KLUG, Stefan, ALPKOKIN, Pelin, BLACK, John, HAYASHI, Yoshitsugu   +3 more
openaire   +1 more source