Results 141 to 150 of about 10,758,453 (263)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Ethical reflections on the use of the category "children with disabilities" in quantitative research. [PDF]

Front Rehabil Sci
Møller-Skau C.
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Meaning-Making Among Family Members of Hospitalized Traffic Accident Victims: A Grounded Theory Study. [PDF]

Cureus
Chamorro Segovia EAJ, Herrera KV, Marquina de Reyes AM, Lopez JDR, Sanchez Murgas O.   +4 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Guardians' willingness to vaccinate primary and secondary school girls against human papillomavirus and associated factors in ethnic autonomous prefectures of Qinghai Province, China: A cross-sectional study based on the Health Belief Model and Theory of Planned Behavior. [PDF]

Hum Vaccin Immunother
Li X, Liu X, Ma G, Wang L, Hu G, Yuan H, A K.   +6 more
europepmc   +1 more source

Seminar “Non-unique factorizations”, Junior Category Theory Seminar, UCLouvain, Louvain-la-Neuve, Belgium.

, 2023
Junior Category Theory Seminar, UCLouvain, Campanini, Federico   +1 more
core  

Hopf formulae for homology of skew braces

The variety SKB of skew (left) braces [1] contains several interesting subcategories as subvarieties, as for instance the varieties of radical rings, of groups and of abelian groups.
Category Theory and Categorical Algebra, Gran, Marino   +1 more
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Reconstructing Life with Chronic Kidney Disease in Contexts of Health Inequality: A Grounded Theory Developed in Chile. [PDF]

Int J Environ Res Public Health
Ramírez-Pereira M.
europepmc   +1 more source