Results 141 to 150 of about 1,420,018 (311)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
UNM Altitude Chamber Operations for Pressure Suit Demonstrations
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Diffusion-driven transient hydrogenation in metal superhydrides at extreme conditions
Nature CommunicationsIn recent years, metal hydride research has become one of the driving forces of the high-pressure community, as it is believed to hold the key to superconductivity close to ambient temperature.
Yishan Zhou +10 more
doaj +1 more source
Hand Grip Strength Demonstration Inside Full Pressure Suit
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A novel rapid cooling assembly design in a high-pressure cubic press apparatus
Matter and Radiation at ExtremesIn traditional high-pressure–temperature assembly design, priority has been given to temperature insulation and retention at high pressures. This limits the efficiency of cooling of samples at the end of experiments, with a negative impact on many ...
Peiyan Wu, Yongjiang Xu, Yanhao Lin
doaj +1 more source
Electrocatalytic upcycling of high-pressure captured CO2 to ethylene
Electrochemical upcycling of captured CO2 under high pressure holds significant potential to bridge between CO2 emissions and hydrocarbon commodities, yet it remains underexplored. Here we convert gas-phase high-pressure captured CO2 into ethylene (C2H4)
Huang, Liang +4 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Synthesis and superconductivity in yttrium-cerium hydrides at high pressures
Nature CommunicationsFurther increasing the critical temperature and/or decreasing the stabilized pressure are the general hopes for the hydride superconductors. Inspired by the low stabilized pressure associated with Ce 4f electrons in superconducting cerium superhydride ...
Liu-Cheng Chen +10 more
doaj +1 more source