Results 51 to 60 of about 140,482 (308)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Suitability of Reduced Pressure Center‐Pivots

Journal of Irrigation and Drainage Engineering, 1984
Selection criteria for reduced pressure center‐pivot irrigation systems are developed. An analysis of the combined effects of the application rate characteristics or center‐pivot irrigation systems and the Soil Conservation Service (SCS) soil intake family curves is used to determine the maximum depth of water which could be applied per irrigation for ...
openaire   +2 more sources

Site Description for the University of Nebraska's Sandhills Agricultural Laboratory [PDF]

, 1985
The Sandhills Agricultural Laboratory is operated by the University of Nebraska. The laboratory is located in the south-central part of the Nebraska Sandhills near Tryon, Nebraska (41 deg. 37' N; 100 deg. 50' W).
Blad, B. L., Gardner, B. R.
core   +1 more source

Relations between concurrent hard X-ray sources in solar flares [PDF]

, 2006
Context: Solar flares release a large fraction of their energy into non-thermal electrons, but it is not clear where and how. Bremsstrahlung X-rays are observed from the corona and chromosphere.
A. O. Benz, Alexander, Battaglia, Benz, Brown, Cliver, Emslie, Fletcher, Fletcher, Frost, Gallagher, Gan, Grigis, Grigis, Hoyng, Hudson, Hurford, Kane, Kiplinger, Lin, Lin, M. Battaglia, Masuda, McTiernan, Parks, Petrosian, Saint-Hilaire, Smith   +27 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Alocação de água e combinação de atividades pela programação linear em um projeto hidroagrícola no município de Guaíra (SP) Water allocation and activity combination in a hydro-agricultural project in Guaíra county (SP), using linear programming

Scientia Agricola, 1994
Com o objetivo de desenvolver um modelo de programação linear para simular os níveis das atividades do processo de produção, utilizou-se o sistema de produção da fazenda Lagoa do Fogão, propriedade da família Sakai, localizada no município de Guaíra,SP ...
J.A. Frizzone, T.A. Botrel, R.A.B. Arce, F.C. Péres   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Improving The Performance of Center-Pivot Irrigation System

Journal of Engineering and Sustainable Development, 2014
The main objective of this research is to elucidate the performance of moved center pivot sprinklers irrigation systems under different conditions, and examine the hydraulic uniformity coefficient according to (Heermann and Hein 2007) under different ...
Khalid Adel Abdelrazaq, Saif Hameed Abed   +1 more
doaj  

Center pivot irrigation in Nebraska : an institutional analysis case study [PDF]

, 1979
This paper is one of a series resulting from institutional analysis of photovoltaic (PV) acceptance. It reports the results of a study of institutional factors influencing acceptance of center-pivot irrigation in the Nebraska agricultural community.
Landers, Stewart, Nutt-Powell, Thomas Evan   +1 more
core   +2 more sources