Results 51 to 60 of about 19,097 (313)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Improving The Performance of Center-Pivot Irrigation System

Journal of Engineering and Sustainable Development, 2014
The main objective of this research is to elucidate the performance of moved center pivot sprinklers irrigation systems under different conditions, and examine the hydraulic uniformity coefficient according to (Heermann and Hein 2007) under different ...
Khalid Adel Abdelrazaq, Saif Hameed Abed   +1 more
doaj  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Effects of water application uniformity using a center pivot on winter wheat yield, water and nitrogen use efficiency in the North China Plain

Journal of Integrative Agriculture, 2020
In recent years, the use of fertigation technology with center pivot irrigation systems has increased rapidly in the North China Plain (NCP). The combined effects of water and nitrogen application uniformity on the grain yield, water use efficiency (WUE)
Dong-yu CAI, Hai-jun YAN, Lian-hao LI
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

ECONOMIC FEASIBILITY OF CENTER PIVOT IRRIGATION WITH CORN, COWPEA, AND SOYBEAN CROPS IN SANDY SOILS [PDF]

Engenharia Agrícola
The use of irrigation enhances productivity, reduces vulnerability to drought and climate variation, and boosts agricultural production. This study aimed to verify the economic viability of implementing center pivot irrigation for corn, cowpea, and ...
Lucas P. Cabreira, Job T. de Oliveira, Fabio H. R. Baio, Rubens A. de Oliveira, Fernando F. da Cunha   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Determination of UAV Flight Altitude and Time for Optimizing Variable-Rate Nitrogen Prescription Maps for Winter Wheat in the North China Plain

Agronomy
An unmanned aerial vehicle (UAV) multi-spectral system provides a monitoring platform to rapidly obtain crop spectral information that can reflect crop nitrogen status for the generation of dynamic variable-rate nitrogen (VRN). To improve the accuracy of
Minne Zhang, Weixia Zhao, Jiusheng Li
doaj   +1 more source

Perceived Displacement explains Wolfpack Effect

Frontiers in Psychology, 2014
We investigate the influence of perceived displacement of moving agent-like stimuli on the performance in dynamic interactive tasks. In order to reliably measure perceived displacement we utilize multiple tasks with different task demands.
Matúš eŠimkovic, Birgit eTräuble
doaj   +1 more source