Cas9‐Embedding Hyperactive TadA8e Confers Efficient and Highly Specific A‐To‐G Base Editing in Rice
ABSTRACT Adenine base editors (ABEs) produce precise A‐to‐G conversion in the genomic target sites without causing double‐strand breaks. However, the hyperactive adenosine deaminase TadA8e raises safety concerns on genome‐wide off‐target edits. We engineered 11 chimeric proteins for ABEs (CP‐ABEs) by embedding hyperactive TadA8e within Cas9 nickase to ...
Jianjian Hu +14 more
wiley +1 more source
A Method for Peripapillary Retinal Vessel Tortuosity Measurement and Its Clinical Correspondence. [PDF]
Zou Y +6 more
europepmc +1 more source
Insights From Two Decades of Seismicity at Columbia Glacier
Abstract We use Columbia Glacier as a case study to demonstrate how seismically cataloged calving events in Alaska can track glacier evolution over two decades. By combining this catalog—a serendipitous byproduct of earthquake monitoring—with terminus positions, bathymetry, glacier thickness, surface velocity, and environmental records, we show how ...
Sebin John +2 more
wiley +1 more source
Computer vision-based steering path visualization of headlands in soybean fields. [PDF]
Ren Y +5 more
europepmc +1 more source
Monte Carlo Simulation of 3D Cloud Radiance Distributions Affected by Ground‐Based Lighting
Abstract Satellite observations of artificial light sources at night are increasing. Clouds, as the most important radiative modulators in the Earth‐atmosphere system, significantly influence the observed values and spatial distribution of the artificial light coming from the ground.
Huixin Sun +3 more
wiley +1 more source
Super‐Resolution Imaging With Fluorotellurite Glass Microspheres
Microsphere lenses made from fluorotellurite glass with a high refractive index and excellent transparency were used to develop a super‐resolution imaging technique and ultramicroscopic objective modules. This approach enables efficient, stable, and precisely controllable imaging with broad potential in life sciences and nanotechnology.
Haonan Zhuo +13 more
wiley +1 more source
AI-driven decision making for intravascular device selection in aortic disease. Current insights and prospects. [PDF]
Dinc R, Ardic N.
europepmc +1 more source
Application of Discontinuity Layout Optimization to Metal Shells and Assemblies
ABSTRACT Discontinuity Layout Optimization (DLO) provides a computationally efficient means of determining collapse loads and associated failure mechanisms across a wide spectrum of plasticity problems. The classical DLO method has focused separately on in‐plane and out‐of‐plane plasticity.
John Valentino +2 more
wiley +1 more source
Enhanced three-dimensional navigation with intraoperative positioning system in coil embolization of complex aneurysm. [PDF]
Murad L +4 more
europepmc +1 more source

