Results 121 to 130 of about 179,568 (266)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A Turning Point for Hepatitis C Care: Point-of-Care Hepatitis C Virus RNA Authorization as a Critical First Step Toward Integrated Test-and-Treat Models in the United States. [PDF]

Clin Infect Dis
Furukawa NW, Kamili S, Wester C.
europepmc   +1 more source

Emerging Authors Program for Global Cardiovascular Disease Research-A collaboration of the U.S. Centers for Disease Control and Prevention, the Lancet Commission on Hypertension Group, Resolve to Save Lives, and the World Hypertension League

Journal of Human Hypertension, 2022
Dinesh Neupane, Bethany Hall, Qaiser Mukhtar, Christian Delles, James E. Sharman, Laura K. Cobb, Daniel T. Lackland, Andrew E. Moran, Michael A. Weber, Michael Hecht Olsen   +9 more
openaire   +3 more sources

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Seasonal Analysis of Candida auris Detection Rates at 80 Wastewater Monitoring Sites in the United States, December 2023-November 2024. [PDF]

Environ Microbiol Rep
Chavez J, Zulli A, Duffy D, Campbell M, Lyman M, Coulliette-Salmond A, Sexton DJ.   +6 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Performance of TB Antigen-Based Skin Tests Amongst Healthcare Workers-Sevagram, India, 2023-2024. [PDF]

Open Forum Infect Dis
Shivkumar PV, Rannaware A, Deshmukh RD, Bhide SM, Deotale VS, Jain J, Mundra A, Kaipilyawar S, Khaparde S, Yeldandi V, Sandhu H, Date A, Narang P, Smith JP, Moonan PK, Ho CS, Garg BS.   +16 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Impact of targeted infection prevention and control interventions on bloodstream infections and colonization with carbapenem-resistant organisms among hospitalized neonates, Bangladesh, 2023-2024. [PDF]

Antimicrob Resist Infect Control
Styczynski A, Keaton A, Mamun GMS, Khan S, Sumon SA, Shuvo TA, Sharmin S, Islam MA, Rahman A, Amin T, Akter J, Halder K, Shahid SB, Parra G, Oakley LP, Wilson K, Patrick M, Harun MGD, Chowdhury F.   +18 more
europepmc   +1 more source