Results 61 to 70 of about 179,568 (266)

Patient tracking and retention with Malawi’s electronic medical records system in antiretroviral treatment clinics

BMC Digital Health
Background Leveraging the widespread availability of the Electronic Medical Records System (EMRS) in Malawi, the Clinic Missed Appointment (CMA) reporting tool was introduced in April 2021 to support the identification and reintegration of antiretroviral
Sterner Msamila, Mbongeni Chizonda, Geoffrey Singini, Veena Sampathkumar, Misheck Luhanga, George Mtonga, Howard Kress, Thulani Maphosa   +7 more
doaj   +1 more source

Electronic health records-based algorithms to screen for U.S. Centers for Disease Control and Prevention tier 1 genetic diseases: a scoping review

Journal of the American Medical Informatics Association
Abstract Objective Missed diagnosis of genetic conditions is a persistent challenge in clinical care, particularly for familial hypercholesterolemia (FH), hereditary breast and ovarian cancer (HBOC), and Lynch syndrome—conditions designated by the U.S.
William R. Harris, Marianna S. Hernandez, Khanh N. H. Ngo, Anne Fladger, Charles A Brunette, Sulaiman R. Hamarneh, Joshua W. Knowles, Matthew S. Lebo, Jason Vassy   +8 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Zika virus prevention behaviors and knowledge among male partners of pregnant people and lack of condom use as a prevention behavior from the Zika en Embarazadas y Niños (ZEN) prospective cohort study, Colombia

BMC Research Notes
Objective Zika virus (ZIKV) infection in pregnancy can cause brain and eye abnormalities and neurodevelopmental sequelae. In the absence of medical countermeasures, behavioral interventions were recommended to prevent mosquito bites and sexual ...
Christina L. Sancken, Ayzsa Tannis, Sandra A. Amouzou, Veronica Burkel, Jeffrey M. Carlson, Suzanne Newton, Suzanne M. Gilboa, Maritza Gonzalez, Diana Valencia, Van T. Tong, Martha Ospina   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Factors associated with PEP awareness among adolescent girls and young women in Eswatini

Journal of the International AIDS Society
Introduction In Eswatini, HIV incidence among adolescent girls and young women (AGYW), aged 15–24 years, is 10 times that of their male peers. Despite the World Health Organization's 2014 recommendation for post‐exposure prophylaxis (PEP) to be available
Anne Laterra, Stephanie Spaid Miedema, Michelle Li, Phumzile Mndzebele, Nozipho Nzuza‐Motsa, Sana Nasir Charania, Katherine Ong, Meagan Cain, Udhayashankar Kanagasabai, Thobile Mkhonta, Laura Chiang, Francis Boateng Annor, Michelle R. Adler   +12 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source