Results 31 to 40 of about 314,452 (257)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Central Africa [PDF]

, 2013
A number of important political and security challenges confront countries in Central Africa, illustrated most vividly by the rapid emergence of a rebel coalition in the Central African Republic (CAR), which gained control of approximately one-third of the country by the end of 2012. Governance concerns, including the lack of inclusive governance,
openaire   +2 more sources

HIGH CYCLE FATIGUE PROPERTIES OF AS-BUILT TI6AL4V (ELI) PRODUCED BY DIRECT METAL LASER SINTERING

South African Journal of Industrial Engineering, 2017
The high cycle fatigue (HCF) properties of direct metal laser sintering (DMLS) of Ti6Al4V (ELI) in three mutually orthogonal build directions were investigated by cycling specimens under load control, in a tension-tension fatigue testing machine.
Malefane, Lerata Botsane , du Preez, W., Maringa, M.   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Quality assurance of peer-assisted learning by measuring academic performance of health sciences extended curriculum students

Perspectives in Education, 2021
Peer-assisted learning (PAL) has numerous benefits in medical curricula. In the extended curriculum programme (ECP) at a university in South Africa, remedial interventions, such as same year/level PAL, were implemented to improve academic success.
Róan Slabbert, Jeanette du Plessis
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Operational Experience of the Rospotrebnadzor Specialists during the Epidemic of Mpox in Eastern and Central Africa in 2024

Проблемы особо опасных инфекций
The paper presents the results of work of the Russian and African experts on the study of the epidemiological and clinical features of mpox in some countries of Eastern (Republic of Rwanda, Uganda, Burundi) and Central (Republic of the Congo) Africa in ...
N. Yu. Pshenichnaya, E. V. Naidenova, M. Yu. Kartashov, G. V. Gopatsa, A. V. Ivanova, L. N. Dmitrieva, I. V. Kutyrev, E. M. Rodnikova, V. Yu. Smolensky, C. Ntirandekura, A. Nsawotebbe, V. Nakintu, N. Gahamanyi, J.-C. Mobousse Misse, A. Yu. Popova   +14 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

A biography of the first Seventh-day Adventist ever to be awarded a university degree in Rwanda: Pastor Ezra Mpyisi

Journal of Educational Studies, 2023
This study describes capturing the life story of an exemplary Seventhday Adventist church member in Rwanda. It aims to present the essential details that led to understanding the participant’s life experiences that may inspire current and future ...
Aurelie Mukabalisa, Jacques Kayigema, William Ruzima Musabyimana   +2 more
doaj   +2 more sources