Results 191 to 200 of about 612,154 (305)

Overview of SARS-CoV-2 genomic surveillance in Central America and the Dominican Republic from February 2020 to January 2023: the impact of PAHO and COMISCA's collaborative efforts. [PDF]

Front Public Health
Herrera Agüero S, Sosa A, Martinez AA, Moreno A, Conde Pereira CR, Gonzalez C, Soto-Garita C, Ulate D, Cordero-Laurent E, Brenes H, Sánchez IM, Mendez-Rico J, Góndola J, Molina Mora JA, Leite J, Franco L, Mendoza L, Gresh L, De La Cruz L, Castro Paz M, Barahona M, Iihoshi N, Chavarría O, Born P, Aguillón RM, Vasquez Cordova RC, Gonzalez S, Alvarado Silva SC, Sandoval López X, Imbert Y, Duarte-Martínez F.   +30 more
europepmc   +1 more source

Media Power in Central America

Cover -- Title Page -- Contents -- Acknowledgments -- Abbreviations -- Introduction -- 1. Honduras and the Media Oligarchy -- 2. El Salvador's Newly Respun Corporatism -- 3. Panama's Media Civil War -- 4. The Return of the Conservatives in Nicaragua -- 5.
Janus, Noreene., Rockwell, Rick.
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Current situation of neuropathology in Central America. [PDF]

Front Oncol
Delgado MN.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Multimodal Cardiac Imaging of a Sudden Cardiac Death Survivor From Central America. [PDF]

JACC Case Rep
Miller DD, Sharma GK, Natla S, Javaheri SP, Arora V.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Aspirin Use Is Protective Against Gastric Cancer in a High-Incidence Region of Central America. [PDF]

Dig Dis Sci
Rifkin SB, Montalvan-Sanchez EE, Norwood DA, Estevez-Ordonez D, Montalvan-Sanchez D, Rodriguez-Murillo A, Dominguez RL, Morgan DR.   +7 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Hashimoto's Encephalopathy With Progressive Cognitive Decline: A Rare Autoimmune Disorder in Central America. [PDF]

Cureus
Hong A, Santos AB, Moya Porras LF, Piedra Pacheco AL, Hong I, Esquivel JE, Villegas JD.   +6 more
europepmc   +1 more source