Results 241 to 250 of about 608,971 (305)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Admixture Mapping of Chronic Kidney Disease and Risk Factors in Hispanic/Latino Individuals From Central America Country of Origin. [PDF]

Circ Genom Precis Med
Horimoto ARVR, Sun Q, Lash JP, Daviglus ML, Cai J, Haack K, Cole SA, Thornton TA, Browning SR, Franceschini N.   +9 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Spatiotemporal Analysis of Malaria Transmission in the Autonomous Indigenous Regions of Panama, Central America, 2015-2022. [PDF]

Trop Med Infect Dis
Cumbrera A, Calzada JE, Chaves LF, Hurtado LA.   +3 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Analysis of Injury Epidemiology in Soccer Players in the 2019 Confederation of North, Central America and Caribbean Association Football Gold Cup as Reported by Team Physicians. [PDF]

Arthrosc Sports Med Rehabil
Forsythe B, Knapik DM, Khazi-Syed D, Chang J, Bohn C, Hand C, Korrapati A, Lavoie-Gagne O, Chiampas G, Mandelbaum BR, Chahla J.   +10 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Solidarity through food: Coping with food insecurity among adolescent migrants in transit through Mexico and Central America. [PDF]

Appetite
Bojórquez I, Infante C, Villanueva-Borbolla MA, Orjuela-Grimm M.   +3 more
europepmc   +1 more source

Potential Biotechnological Applications of Venoms from the <i>Viperidae</i> Family in Central America for Thrombosis. [PDF]

Toxins (Basel)
Chang Estrada JE, Guerrero TN, Reyes-Enríquez DF, Nardy ES, Guimarães Ferreira R, Ruiz Calderón CJ, Wellmann IA, Monteiro Espíndola KM, do Prado AF, Soares AM, Fontes MRM, Chagas Monteiro M, Zingali RB.   +12 more
europepmc   +1 more source

Molecular Detection of <i>Leishmania</i> (<i>V.</i>) <i>braziliensis</i> and <i>Leishmania</i> (<i>M.</i>) <i>martiniquensis</i> Infecting Domestic Animals from Panama, Central America. [PDF]

Animals (Basel)
Pineda V, Calzada JE, Montilla S, Rodríguez I, Howard E, Torres AI, Vasquez V, Reina A, Saldaña A, González K.   +9 more
europepmc   +1 more source