Results 241 to 250 of about 612,154 (305)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Analysis of Injury Epidemiology in Soccer Players in the 2019 Confederation of North, Central America and Caribbean Association Football Gold Cup as Reported by Team Physicians. [PDF]

Arthrosc Sports Med Rehabil
Forsythe B, Knapik DM, Khazi-Syed D, Chang J, Bohn C, Hand C, Korrapati A, Lavoie-Gagne O, Chiampas G, Mandelbaum BR, Chahla J.   +10 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Admixture Mapping of Chronic Kidney Disease and Risk Factors in Hispanic/Latino Individuals From Central America Country of Origin. [PDF]

Circ Genom Precis Med
Horimoto ARVR, Sun Q, Lash JP, Daviglus ML, Cai J, Haack K, Cole SA, Thornton TA, Browning SR, Franceschini N.   +9 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Spatiotemporal Analysis of Malaria Transmission in the Autonomous Indigenous Regions of Panama, Central America, 2015-2022. [PDF]

Trop Med Infect Dis
Cumbrera A, Calzada JE, Chaves LF, Hurtado LA.   +3 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Solidarity through food: Coping with food insecurity among adolescent migrants in transit through Mexico and Central America. [PDF]

Appetite
Bojórquez I, Infante C, Villanueva-Borbolla MA, Orjuela-Grimm M.   +3 more
europepmc   +1 more source

Molecular Detection of <i>Leishmania</i> (<i>V.</i>) <i>braziliensis</i> and <i>Leishmania</i> (<i>M.</i>) <i>martiniquensis</i> Infecting Domestic Animals from Panama, Central America. [PDF]

Animals (Basel)
Pineda V, Calzada JE, Montilla S, Rodríguez I, Howard E, Torres AI, Vasquez V, Reina A, Saldaña A, González K.   +9 more
europepmc   +1 more source

Potential Biotechnological Applications of Venoms from the <i>Viperidae</i> Family in Central America for Thrombosis. [PDF]

Toxins (Basel)
Chang Estrada JE, Guerrero TN, Reyes-Enríquez DF, Nardy ES, Guimarães Ferreira R, Ruiz Calderón CJ, Wellmann IA, Monteiro Espíndola KM, do Prado AF, Soares AM, Fontes MRM, Chagas Monteiro M, Zingali RB.   +12 more
europepmc   +1 more source