Results 71 to 80 of about 10,981,056 (291)

Aortic stiffness in lone atrial fibrillation: a novel risk factor for arrhythmia recurrence. [PDF]

PLoS ONE, 2013
BackgroundRecent community-based research has linked aortic stiffness to the development of atrial fibrillation. We posit that aortic stiffness contributes to adverse atrial remodeling leading to the persistence of atrial fibrillation following catheter ...
Dennis H Lau, Melissa E Middeldorp, Anthony G Brooks, Anand N Ganesan, Kurt C Roberts-Thomson, Martin K Stiles, Darryl P Leong, Hany S Abed, Han S Lim, Christopher X Wong, Scott R Willoughby, Glenn D Young, Jonathan M Kalman, Walter P Abhayaratna, Prashanthan Sanders   +14 more
doaj   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

DETERMINANTS OF CENTRAL AORTIC PRESSURE, AUGMENTATION AND AMPLIFICATION IN THE GENERAL POPULATION OF NOVOSIBIRSK

Атеросклероз, 2017
Objective. Currently increasing attention to the parameters of central aortic pressure (cAP). The study associations of cAP, its augmentation and amplification, with a number of metabolic parameters in the general population of Novosibirsk is of interest.
E. E. Tsvetkova, A. A. Kuznetsov, D. V. Denisova, Yu. I. Ragino, M. I. Voevoda   +4 more
doaj  

Effectiveness of Chrono-Pharmacotherapy Depending on the Salt Sensitivity of Patients with Arterial Hypertension and Diabetes Mellitus Type 2

Рациональная фармакотерапия в кардиологии, 2019
Aim. To study the effect of two regimens of combined antihypertensive therapy during the day on daily monitoring of arterial pressure, central aortic pressure, and arterial stiffness, depending on the salt sensitivity of hypertensive patients with ...
V. V. Skibitskiy, A. A. Kiselev, A. V. Fendrikova   +2 more
doaj   +1 more source

Evaluating daily profile of central aortic pressure and reflected pulse wave parameters in climacteric women

BMC Cardiovascular Disorders, 2021
Introduction Structural and functional changes of the vascular wall in women occur already at the very early stages of reproductive aging. An emergence of applanation tonometry made it possible to evaluate arterial stiffness and central hemodynamic ...
Sergey N. Tolstov, Igor A. Salov, Anton R. Kiselev, Andrey P. Rebrov   +3 more
doaj   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

3.6 NON-INVASIVE, MRI-BASED ESTIMATION OF PATIENT-SPECIFIC AORTIC BLOOD PRESSURE USING ONE-DIMENSIONAL BLOOD FLOW MODELLING

Artery Research, 2017
Background and objectives: Clinical evidence shows that central (aortic) blood pressure (CBP) is a better marker of cardiovascular risk than brachial pressure [1]. However, CBP can only be accurately measured invasively, through catheterisation.
Jorge Mariscal Harana, Arna van Engelen, Torben Schneider, Mateusz Florkow, Peter Charlton, Bram Ruijsink, Hubrecht De Bliek, Israel Valverde, Marietta Carakida, Kuberan Pushparajah, Spencer Sherwin, Rene Botnar, Jordi Alastruey   +12 more
doaj   +1 more source

Quantification of the Calibration Error in the Transfer Function-Derived Central Aortic Blood Pressures [PDF]

American Journal of Hypertension, 2011
The accuracy of the central aortic systolic (SBP-C) and pulse (PP-C) blood pressures estimated noninvasively by a generalized transfer function technique has been questioned. The purpose of the present study was to quantify precisely the impact of the input errors (differences between the oscillometric (SBP-O, DBP-O, PP-O) and invasive (SBP-B, DBP-B ...
Yuan-Ta, Shih, Hao-Min, Cheng, Shih-Hsien, Sung, Wei-Chih, Hu, Chen-Huan, Chen   +4 more
openaire   +2 more sources

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source