Results 131 to 140 of about 369,513 (318)

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming

Advanced Science, EarlyView.
Spatially resolved multiomics reveals that high‐copper zones are closely associated with tumor metastasis, immune‐desert phenotypes, and oxidative‐phosphorylation (OXPHOS)‐dependent proliferation. A targeted bacterial nanovesicle delivering copper‐depleting agents effectively reduces tumor copper levels, inhibits OXPHOS‐dependent tumor growth, and ...
Lin Chen, Saibo Ma, Hao Wu, Lingna Zheng, Yunpeng Yi, Guangnian Liu, Baoyi Li, Jiayi Sun, Yang Du, Bing Wang, Yike Liu, Cheng Zhang, Jing Chang, Yuheng Pang, Wenjing Wang, Meng Wang, Motao Zhu   +16 more
wiley   +1 more source

New Twists In The Study Of Gravity Wave Emission In Systems With Massive Black Holes [PDF]

arXiv, 1996
Traditionlly, gravitational wave emission from a coalescing binary system is computed using point mass approximations without considering any accretion disk. However, it is believed that in many of the galactic nuclei, there are supermassive central black holes surrounded by accretion disks.
arxiv  

Description of a new Rodent from Central Asia [PDF]

, 1876
James Wood-Mason
openalex   +1 more source

Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease

Advanced Science, EarlyView.
Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du, Akiko Mizokami, Junjun Ni, Simeng Zhang, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Isei Tanida, Takashi Kanematsu   +8 more
wiley   +1 more source

Radiocarbon chronology and settlement patterns in the Bronze Age of the Qaidam Basin, Northwestern China

Scientific Reports
Prehistoric settlement patterns on the Tibetan Plateau, particularly in the Qaidam Basin, have drawn significant scholarly interest. Yet, limited data have hindered a comprehensive understanding the Bronze Age chronology and landscape exploitation in ...
Ben Li, Jian Ma, Honghai Chen, Meng Guo, Jiyuan Li, Meng Ren, Hongxian Yan, Yongming Xiao, Marcella Festa   +8 more
doaj   +1 more source

How Good are LLMs at Relation Extraction under Low-Resource Scenario? Comprehensive Evaluation [PDF]

arXiv
Relation Extraction (RE) serves as a crucial technology for transforming unstructured text into structured information, especially within the framework of Knowledge Graph development. Its importance is emphasized by its essential role in various downstream tasks.
arxiv  

An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

Advanced Science, EarlyView.
The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T.K. Boopathy, Aravind Sivakumar, Cheng‐Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine F. Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty   +20 more
wiley   +1 more source

Art. XIV.—Russian Central Asia [PDF]

, 1891
C. E. Biddulph
openalex   +1 more source

Origins, Dispersal, and Impact: Bidirectional Introgression Between Chinese and European Pig Populations

Advanced Science, EarlyView.
This study investigates bidirectional introgression between Chinese and European pig populations, revealing 3558 introgressed genomic segments and 30 structural variations. Analysis of the BMP2 region suggests its role in body size enhancement. By integrating ancient and modern genomes, the study highlights the impact of introgression on genetic ...
Yibin Qiu, Langqing Liu, Min Huang, Donglin Ruan, Rongrong Ding, Zebin Zhang, Enqin Zheng, Shiyuan Wang, Shaoxiong Deng, Xianglun Meng, Xinyan Cheng, Jiaxin Shi, Yingshan Yang, Fuchen Zhou, Sixiu Huang, Huaqiang Yang, Zicong Li, Gengyuan Cai, Zhenfang Wu, Jie Yang   +19 more
wiley   +1 more source

Outbreak of Crimean-Congo hemorrhagic fever in Kyzylorda region, Kazakhstan, March–July 2022

Frontiers in Public Health
BackgroundCrimean–Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease characterized by a high case fatality rate of ~30%. CCHF is endemic in Kyzylorda Oblast, Kazakhstan, which has a population of 800,000, with approximately 10 cases reported
Saya Gazezova, Saya Gazezova, Malika Gabdullina, Gulzhan Ayapova, Dilyara Nabirova, Dilyara Nabirova, Michelle Waltenburg, Manar Smagul, Manar Smagul, Lena Kasabekova, Lena Kasabekova, Umirbek Ussenov, Roberta Horth, Roberta Horth   +13 more
doaj   +1 more source