Results 191 to 200 of about 6,302,413 (368)

Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

Advanced Science, EarlyView.
Based on the poor cartilage penetration of tFNA, a novel tFNA‐2WL with excellent cartilage permeability and perfect chondrocyte endocytosis properties is designed and fabricated. As a result, tFNA‐2WL has a nearly seven‐fold increase in the penetration depth into the cartilage, with the same excellent cell entry properties as tFNA.
Kui Huang, Qiumei Li, Huixuan Lin, Qian Shen, Yaping Wu, Taoran Tian, Chuan Ma, Sirong Shi, Jingang Xiao, Yunfeng Lin   +9 more
wiley   +1 more source

MIGRATION REGULATION ISSUES IN CENTRAL ASIA

Halyk̦aralyk̦ k̦atynastar ža̋ne halyk̦aralyk̦ k̦u̇k̦yk̦ seriâsì, 2016
Миграционные процессы в Центральной Азии являются одной из ключевых характеристик трансформации государств региона и важным звеном, прочно связывающим эти государства.
Л. Ф. Деловарова
doaj  

Dr. Sven Hedin on Central Asia [PDF]

, 1909

openalex   +1 more source

Water Conflict and Cooperation in Central Asia [PDF]

human development, water ...
Erika Weinthal
core  

Superelastic and Ultra‐Soft MXene/CNF Aerogel@PDMS‐Based Dual‐Modal Pressure Sensor for Complex Stimuli Monitoring

Advanced Science, EarlyView.
A triboelectric‐piezoresistive dual‐modal pressure sensor based on superelastic and ultrasoft MXene/cellulose nanofiber (CNF) aerogel@PDMS is fabricated. The sensor exhibits high sensitivity and stable sensing performance via a dual mechanism. Through the effective combination of these two mechanisms, comprehensive monitoring of complex stimuli can be ...
Ao Wang, Zhenqiu Gao, Shaokuan Wu, Yihan Wei, Bohan Lu, Jia Shi, Lanyue Shen, Yina Liu, Xuhui Sun, Zhen Wen   +9 more
wiley   +1 more source

Central Asian Exploration 1 [PDF]

, 1904
T. H. H.
openalex   +1 more source

Pension Reform in Central Asia: An Overview [PDF]

Seven years ago, Kazakhstan embarked on a dramatic reform of its pension and social security system in order to move from a public defined benefit ("solidarity") system to one of defined mandatory contributions (accumulative system).
Becker, Charles M., Seitenova, Ai-Gul S., Urzhumova, Dina S.   +2 more
core  

An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer

Advanced Science, EarlyView.
This study presents an explainable multimodal AI model, MAIGGT (Multimodal Artificial Intelligence Germline Genetic Testing), that combines whole‐slide histopathology with clinical data for accurate germline BRCA1/2 mutation prescreening. By integrating digital pathology and EHR phenotypes, MAIGCT enables cost‐effective, scalable hereditary breast ...
Zijian Yang, Changyuan Guo, Jiayi Li, Yalun Li, Lei Zhong, Pengming Pu, Tongxuan Shang, Lin Cong, Yongxin Zhou, Guangdong Qiao, Ziqi Jia, Hengyi Xu, Heng Cao, Yansong Huang, Tianyi Liu, Jian Liang, Jiang Wu, Dongxu Ma, Yuchen Liu, Ruijie Zhou, Xiang Wang, Jianming Ying, Meng Zhou, Jiaqi Liu   +23 more
wiley   +1 more source

CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He, Zi‐Yi Wang, Bin Xu, Cheng‐Jie Zhong, Lu‐Na Wang, Huan‐Chen Shi, Zi‐Yue Yang, Shi‐Qi Zhou, Hui Li, Bo Hu, Xiao‐Dong Zhu, Ying‐Hao Shen, Jian Zhou, Jia Fan, Hui‐Chuan Sun, Cheng Huang   +15 more
wiley   +1 more source

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source