Results 51 to 60 of about 19,804 (295)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Social trust and central-bank independence [PDF]
European Journal of Political Economy, 2012 Central banks have become more independent in many countries. A common rationale has been the existence of a credibility (or lack-of-trust) problem for monetary policy.
Berggren, Niclas +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 1992 Europe is in the midst of a historically unique process of fundamental reform. The driving vision in European politics apparently is to develop a European Union which will be both, economic and political union. While the debate on the political structure has hardly begun, the basic microeconomic principles of Economic and Monetary Union (EMU) have been
Eijffinger, S.C.W., Schaling, E.
openaire +3 more sources
The Case for Central Bank Independence
PSL Quarterly Review, 1992 This paper reviews arguments for central bank independence and presents new evidence on the impact of central bank (in)dependence on the level and variability of inflation, money growth, the level and financing of government budget deficits and economic ...
Jakob De Haan, Jan Egbert Sturm
doaj
Central bank independence in another eleven countries
PSL Quarterly Review, 2013 The rationale for the independence of central banks is the so-called 'Rules versus Discretion' debate, which is described in this article. Central bank independence is considered an effective measure against governments from manipulating policy ...
S. EIJFFINGER, M. VAN KEULEN
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Brazilian Journal of Political Economy, 2006 Nowadays, the belief is strong in the Brazilian federal government that operational central bank independence is a basic condition to assure price stability.
Helder Ferreira de Mendonça
doaj +1 more source
Theoretical concept of Central Bank independence and legal status of the National Bank of Serbia [PDF]
Bankarstvo, 2017 The modern theoretical concept of independence is crucial for the establishment of institutional arrangements relating to monetary authority. It is theoretically demonstrated and empirically verified that a central bank can function effectively only if ...
Ilić Nikola
doaj +1 more source