Results 271 to 280 of about 4,795,791 (345)

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Cell bank system, establishment, and application in the virus research, diagnosis, and biopharmaceutical industries. [PDF]

Biotechnol Notes
Soleimani S, Ghorani M.
europepmc   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Synergistic review of automation impact of big data, AI, and ML in current data transformative era. [PDF]

F1000Res
Rath S, Pandey M, Rautaray SS.
europepmc   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Socio-cultural challenges and mental health needs of female sex workers in Bangladesh: a call for culturally sensitive interventions. [PDF]

Int J Equity Health
Rahaman MA, Shamma FT.
europepmc   +1 more source

Characteristics and dynamic evolution of inter-industry volatility spillovers in China's stock market. [PDF]

PLoS One
Xie F, Wei H.
europepmc   +1 more source

An opportunity for fertility preservation in neurosurgical spinal ependymoma patients: a single center review. [PDF]

Front Reprod Health
Michles MJ, Schroeder CB, Sugarmann LR, Sun FW, Kruzan M, Kassi L, Sauerbrun-Cutler MT, Gokaslan ZL, Sullivan PZ.   +8 more
europepmc   +1 more source

How FAIR is metadata for human pluripotent stem cells? [PDF]

Stem Cell Reports
Hu M, Ankeny RA, Santos D, Wells CA.
europepmc   +1 more source

Immunotherapy with lymphocytes derived from banked tumor tissue in two refractory NSCLC patients with leptomeningeal metastases: a report of two cases. [PDF]

Transl Lung Cancer Res
Zheng AH, Yu C, Su YR, Peng M, Chen JY, Wang FW, Zhu XM, Yan PY, Wang HT, Shen J, Chen WJ, Li Q, Chen Y, Chen Y, Wang YS, Gu HY, Meng ZN, Zhao JW, Ni WM, Wang TH, Wu SL, Li M, Wang Z, Cheng AP, Huang XX, Yang ZY, Jiang JH, Wang QJ, Qu J, Zhang ST, Shi KK, Zhang HX, Zhang DH, Wu GQ.   +33 more
europepmc   +1 more source