Results 111 to 120 of about 6,753,378 (308)
Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography
Advanced Science, EarlyView.Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian +12 more
wiley +1 more source
Latin American Journal of Central BankingThe policies adopted in Chile to mitigate the impact of the Covid-19 pandemic stand out for their magnitude: they implied an increase in the liquidity of the household sector of 29 % of the 2019 GDP in an interval of 18 months.
Enzo Cerletti +4 more
doaj +1 more source
Advanced Science, EarlyView.Our findings establish SUMOylation as a key post‐translational control layer in auxin signaling. We show that SIZ1‐mediated SUMOylation of LBD29 promotes its association with ARF7, stabilizing a transcriptional hub that governs lateral root development.
Jiaxuan Sui +7 more
wiley +1 more source
Credibility and Inflation Targeting in an Emerging Market: The Case of Chile [PDF]
When the monetary authority lacks credibility it faces a larger trade-off between output and inflation. This poses important challenges for the implementation and design of an inflation targeting regime and an inflation stabilization process.
Luis F. Céspedes, Claudio Soto
core
Chile 96: análisis y opiniones [PDF]
Chile continuó creciendo en 1996. El Producto Interno Bruto (PIB) se incrementó en un 7,2%, completándose más de una década de crecimiento ininterrumpido y con una tasa promedio superior al 6,5% anual. La tasa de desocupación en 1996 fue de un 6,5%.
FLACSO Chile
core +1 more source
Estimating the output gap in times of COVID-19
Latin American Journal of Central BankingWe extend a standard multivariate filter used to estimate the Output Gap (OG) in Chile to account for large economic shocks, such as those observed during the COVID-19 crisis. We propose two methodological extensions. First, we introduce exogenous supply
Luigi Durand, Jorge Alberto Fornero
doaj +1 more source
[Medical specialization in Chile. A centralized vision].
Revista medica de Chile, 2018 Medical graduates face different postgraduate training options, but their priority is to obtain a primary medical specialty, defined as a specialty that does not derive from other. There are different specialty training programs in Chile, which can be dependent or independent of the Ministry of Health.
Diego E, Clouet-Huerta +2 more
openaire +1 more source
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
The Transactions Demand for Money in Chile [PDF]
This paper examines the transactions demand for money in Chile over the period from 1986 to 2000. Using systems cointegration methods suggested by Johansen (1995), we find that although macroeconomic data for Chile exhibit strong trend-stationarity ...
Christopher Adam
core
Advanced Science, EarlyView.This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo +17 more
wiley +1 more source