Results 181 to 190 of about 944,652 (357)

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Rentabilidad de la educación en microemprendedores: Los retornos por nivel educativo en la región de Valparaíso, Chile

Ingeniare: Revista Chilena de Ingeniería
La educación y el emprendimiento son considerados motores fundamentales para el desarrollo de una sociedad. El presente estudio tiene como propósito realizar un análisis de la rentabilidad de la educación en el sector emprendedor.
Valeria Scapini Sánchez, Pedro Gallardo Flores, Skander López Galbán   +2 more
doaj  

Composition of Necrophagous Insect Assemblages in Altitudinal Gradient of Central Chile. [PDF]

Insects
Marzolo Bown M, Thyssen PJ, Marrara Prado A, Villagra C.   +3 more
europepmc   +1 more source

B-value variations in the Central Chile seismic gap assessed by a Bayesian transdimensional approach. [PDF]

Sci Rep, 2022
Morales-Yáñez C, Bustamante L, Benavente R, Sippl C, Moreno M.   +4 more
europepmc   +1 more source

Geochemical baselines based on stream waters: applications to environmental studies, Central Chile as a case study

, 2013
J. A. Keeling Fernando Zuniga
openalex   +2 more sources

Resolvin D5 Inhibits CXCL8 Expression in Colonic Epithelial Cells Through Activating GPR101 to Impede Neutrophil Recruitment and Consequently Alleviate Ulcerative Colitis

Advanced Science, EarlyView.
RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo, Yilei Guo, Yanrong Zhu, Ke Yan, Yulai Fang, Jiafeng Zhang, Yue He, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
wiley   +1 more source

High Prevalence of Food Insecurity and Associated Risk Factors in Chilean and Immigrant Women from South-Central Chile. [PDF]

Foods
Rodríguez-Fernández A, Delgado-Saborit JM, Carrasco P, Cormick G, Ruiz-de la Fuente M, Maury-Sintjago E.   +5 more
europepmc   +1 more source

Abundance and associated factors of Amblyomma tigrinum (Acari: Ixodidae) infesting wild foxes in north-central Chile. [PDF]

Rev Bras Parasitol Vet, 2023
Hernández F, Manqui J, González-Acuña D, Beltrami E, Verdugo C, Acosta-Jamett G.   +5 more
europepmc   +1 more source

Direct measurement and prediction of bulk density on alluvial soils of central Chile [PDF]

, 2016
Manuel Casanova, Elizabeth Tapia, Óscar Seguel, Osvaldo Salazar   +3 more
openalex   +1 more source

Modelling the Effects of Changes in Forest Cover and Climate on Hydrology of Headwater Catchments in South-Central Chile [PDF]

, 2020
Guillermo Barrientos, Albert Herrero, Andrés Iroumé, Oscar Mardones, Ramón J. Batalla   +4 more
openalex   +1 more source