Results 181 to 190 of about 6,753,378 (308)

Heavy Metal Contamination in Edible Species from Quintero-Puchuncaví Bay: Risks Associated with the Icon Industrial Complex in Central Chile. [PDF]

Toxics
Curaz-Leiva S, Díaz MJ, Sola I, Ruiz J, Pérez M, González-Labra D, Paredes-Ocaranza B, Lobos MG, Lavergne C, Klarian SA, Molina V, Sáez CA.   +11 more
europepmc   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Complete genome sequence of <i>Rhodococcus erythropolis</i> strain ICBD2, isolated from hydrocarbon-polluted coastal sediments in Central Chile. [PDF]

Microbiol Resour Announc
Báez-Matus X, Durán RE, Orellana R, Cumsille A, Rivera EG, Esparza-Correa T, Salvà-Serra F, Jaén-Luchoro D, Moore ERB, Seeger M.   +9 more
europepmc   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Separating tectonic and climate signals in Holocene sea-level records using marine terraces in central Chile. [PDF]

Sci Rep
Melnick D, Jara-Muñoz J, Garrett E, Plissart G, Freisleben R, Strecker MR.   +5 more
europepmc   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

Eyrie Student Union; interior; homecoming dance

Students dance at a Central Methodist University (formerly Central College) homecoming dance, located inside the Eyrie Student ...
Central Methodist University, Smiley Memorial Library
core  

Taxonomic Validation and Southern Range Expansion of <i>Campsomeriella whitelyi</i> (Kirby, 1889) (Hymenoptera: Scoliidae: Campsomerini) in Agricultural Landscapes of North-Central Chile. [PDF]

Insects
González-Dossi M, Alfaro FM, Villalobos EV, Pizarro-Araya J.   +3 more
europepmc   +1 more source

Filarial nematodes in domestic dogs and mosquitoes (Diptera: Culicidae) from semi-rural areas in Central Chile. [PDF]

Front Vet Sci, 2023
Cancino-Faure B, González CR, Piñeiro González A, Pinochet S, Bustos S, Morchón R, Piñeiro Cazaux A, Quezada Aguilar I, Salas Espinoza M, Acevedo Salgado R, Barra Díaz C, Segovia C, Lozada-Yavina R, Álvarez Rojas CA.   +13 more
europepmc   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source