Results 71 to 80 of about 58,447 (265)

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

La media prescripción frente al delito de desaparición forzada de personas. ¿Incumplimiento de la normativa internacional en materia de crímenes de lesa humanidad?

Revista Direito GV, 2014
El presente trabajo se presenta como un estudio del tratamiento de la media prescripción aplicada a los crímenes de desaparición forzada de personas. Los autores abordan la problemática desde una perspectiva jurídica e histórica.
Isabel González Ramírez, Samuel Malamud Herrera, María Soledad Fuentealba Martínez, Florencio Pardo Montenegro   +3 more
doaj  

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Diversidad de micromamíferos en tres ambientes de la Reserva Nacional Lago Peñuelas, Región de Valparaíso, Chile Diversity of small mammals in three environments of the National Reserve Lago Peñuelas, Región de Valparaíso, Chile

Gayana, 2010
Los ecosistemas mediterráneos de Chile, los únicos en Sudamérica de los cuatro presentes en el mundo, son considerados áreas prioritarias para la conservación, por su alta concentración de especies endémicas y las aceleradas tasas de destrucción del ...
Andrés Muñoz-Pedreros, Susan Fletcher, José Yáñez, Pamela Sánchez   +3 more
doaj  

Acari, Laelapidae (ectoparasitic mites), central and southern Chile

Check List, 2010
Laelapidae mites include ectoparasites of small mammals. The fauna of mites of many Neotropical areas is still understudied, and such is the case of Chile. We report the results of a survey carried out in central and southern Chile: Acanthochela chilensis Ewing 1933 is reported from Dromiciops gliroides Thomas 1894; Lukoschus maresi Radovsky and ...
Lareschi, Marcela, González Acuña, Daniel   +1 more
openaire   +4 more sources

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

A time-energy analysis of daytime surface activity in degus, Octodon degus Análisis del uso de tiempo y energía en la actividad superficial diaria en degus, Octodon degus

Revista Chilena de Historia Natural, 2002
We present an analysis of time and energy allocation in a day-active caviomorph rodent, the degu, Octodon degus, in central Chile. We quantified components of surface activity in the field on a daily basis in individual degus near the time of the summer ...
G.J. Kenagy, Rodrigo A. Vásquez, Roberto F. Nespolo, Francisco Bozinovic   +3 more
doaj  

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Activismos creativos en la comunidad soviet wave: fantasmas de un futuro soñado

Designio. Investigación en Diseño Gráfico y Estudios de la Imagen
El objetivo de este artículo es estudiar las imágenes del género musical soviet wave a partir de la función estética de la nostalgia como resultado de la ruptura temporal que significó la caída de la ex Unión Soviética y otros desastres aunados, como el ...
Ingrid Sánchez Téllez, Juan Contreras Escobar, Claudio Contreras Escobar   +2 more
doaj   +1 more source