Advanced Experiment Design Strategies for Drug Development
Advanced Intelligent Discovery, EarlyView.Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang +3 more
wiley +1 more source
High-Performance Liquid Chromatography Method Optimization and Validation for Potassium Bromate Detection in Bread Using a Quality-by-Design Approach. [PDF]
J Anal Methods ChemGebretsadikan T +5 more
europepmc +1 more source
Toward Intelligent Multimodal Holography for Real‐Time Chemical Imaging of Dynamic Ion Separation
Advanced Intelligent Discovery, EarlyView.Intelligent multimodal holography integrates digital off‐axis holography, spectroscopic imaging, and AI‐driven reconstruction to visualize ion transport and chemical dynamics in real time. In this perspective paper, we outline how this approach enables label‐free, chemically specific monitoring of complex environments and discuss its potential to ...
Giovanna Ricchiuti +3 more
wiley +1 more source
Optimization of Multi-gravity Separator (MGS) Parameters for Specularite Ore Beneficiation: Evaluating Box-Behnken and Central Composite Designs. [PDF]
ACS OmegaÇerik Ç, Şen S.
europepmc +1 more source
In Situ Contact Angle Measurement for Autonomous Spin Coating in Self‐Driving Labs
Advanced Intelligent Discovery, EarlyView.A vision‐based add‐on transforms commercial spin coaters into autonomous modules of Self‐Driving Labs. Combining a width‐scaled U‐Net with classical geometric analysis, the system simultaneously measures contact angles and estimates substrate pose using a single camera.
Sven Fischer, Micha Hiegle, Holger Röhm
wiley +1 more source
Angewandte Chemie, EarlyView.A mechanically adaptive interface enhances the stability and cycling performance of lithium metal all‐solid‐state batteries, particularly under low pressure. The interface design synergistically integrates indium fluoride with polyrotaxane, where the inorganic component effectively suppresses lithium dendrite formation and the organic component ...
Jihoon Oh +3 more
wiley +2 more sources
The Effect of Ultraviolet Modification on the Performance of Polyamide Fiber-Reinforced Cement Mortars: Optimization and Characterization Using Response Surface Methodology. [PDF]
Polymers (Basel)Akarsu Özenç A +3 more
europepmc +1 more source
Bubbles Acting as Micro End‐Effectors for Dexterous Manipulation and Sensing in Aqueous Environment
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.Inspired by bubbles, this article proposes a low‐cost method for multifunctional manipulation and sensing using microbubbles in aqueous environments. Bubbles are easily generated in situ, enabling the safe and adaptive handling of microobjects and sensing of microforces and surface textures.
Zichen Xu, Qingsong Xu
wiley +1 more source
Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Arformoterol Tartrate Inhalation Solution Dosage Form via RP-HPLC. [PDF]
ACS OmegaAlluri NR +3 more
europepmc +1 more source
Microrobotic Catheterization of the Ophthalmic Artery for Targeted Treatment of Retinoblastoma
Advanced Intelligent Systems, EarlyView.A microrobotic platform is presented that allows teleoperated and autonomous navigation of flow‐driven magnetic microcatheters, MagFlow, into the ophthalmic artery for superselective intra‐arterial infusion of chemotherapy to treat retinoblastoma. Extensive benchtop validations with patient‐derived biomimetic phantoms under optical and fluoroscopic ...
Artur Banach +5 more
wiley +1 more source