Results 181 to 190 of about 6,217,741 (298)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Nitrogen vacancies in graphitic carbon nitride and their role in heterogeneous photocatalysis.

Mater Horiz
Landi A, Ambrosio F, Bianchi N, Loriso M, Malavasi L, Profumo A, Wiktor J, Peluso A.   +7 more
europepmc   +1 more source

A Framework to Optimize Channel and Active Area Usage in Multicore Fibers for Needle Shape Sensing. [PDF]

J Med Robot Res
Huk K, Francoeur J, Ma Y, Kim JS, Iordachita I.   +4 more
europepmc   +1 more source

Inverse problem of central configurations in the collinear 5-body problem

, 2018
Candice Davis, Scott P. Geyer, W. Johnson, Zhifu Xie   +3 more
semanticscholar   +1 more source

On Strictly Convex Central Configurations of the 2n-Body Problem

Journal of Dynamics and Differential Equations, 2018
E. Barrabés, J. M. Cors
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Tailored Spin Coupling of Single-Molecule Magnets with a Single Charge-Density-Wave Metal Layer. [PDF]

J Am Chem Soc
Zhang C, Zhou F, Jin H, Zhou L, Dong Z, Ren M, Zhang Q, Yang H, Xu X, Ma YX, Chen L, Jung TA, Huang B, Gao HJ, Zhang Y, Wang Y.   +15 more
europepmc   +1 more source

A family of stacked central configurations in the planar five-body problem

, 2017
J. Cornelio, M. Álvarez-Ramírez, J. M. Cors   +2 more
semanticscholar   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Machine learning-optimized graphene-integrated refractory metasurface for broadband solar energy harvesting. [PDF]

Sci Rep
Elsayed HA, Solouma E, Wekalao J, Mehaney A, Messaoudi M, Rajakannu A, Rabie AM, Zoubi WA.   +7 more
europepmc   +1 more source