Results 51 to 60 of about 13,031,197 (236)

Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival. [PDF]

PLoS ONE, 2017
Type 1 diabetes is an autoimmune disease that destroys insulin-producing beta cells in the pancreas. Pancreatic islet transplantation could be an effective treatment option for type 1 diabetes once several issues are resolved, including donor shortage ...
Hirotake Komatsu, Colin Cook, Chia-Hao Wang, Leonard Medrano, Henry Lin, Fouad Kandeel, Yu-Chong Tai, Yoko Mullen   +7 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Central core disease

, 2004
Central core disease is a congenital myopathy characterized by generalized hypotonia, muscle weakness and presence of central cores on muscle biopsy. It generally presents during infancy.
Salhotra, Amandeep, Kalra, Veena, Sarkar, Chitra, Gulati, Sheffali, Sharma, M. C.   +4 more
core   +1 more source

Network Structure of Depressive Symptomatology in Elderly with Cognitive Impairment

Medicina
Objective and objectives: Patients with cognitive disorders such as Alzheimer’s disease (AD) and mild cognitive impairment (MCI) frequently exhibit depressive symptoms. Depressive symptoms can be evaluated with various measures and questionnaires.
Jeehyung Pyo, Hyukjun Lee, Jakyung Lee, Daseul Lee, Hyeona Yu, Shinn-Won Lim, Woojae Myung, Doh-Kwan Kim   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Social representation of Hansen's disease thirty years after the term 'leprosy' was replaced in Brazil

História, Ciências, Saúde: Manguinhos, 2003
Based on the theories of social representation (SC) and Central Core (CC), a structural study was undertaken regarding the neologism hanseníase (Hansen's disease), the term adopted by Brazil's Ministry of Health in the 1970s.
Oliveira Maria Leide Wand-del-Rey de, Mendes Carla Maria, Tardin Rachel Tebaldi, Cunha Mônica Duarte, Arruda Angela   +4 more
doaj  

Depletion of core microbiome forms the shared background against diverging dysbiosis patterns in Crohn’s disease and intestinal tuberculosis: insights from an integrated multi-cohort analysis

Gut Pathogens
Background/aims Crohn’s disease (CD) and intestinal tuberculosis (ITB) are gastrointestinal (GI) inflammatory disorders with overlapping clinical presentations but diverging etiologies.
Aditya Bajaj, Manasvini Markandey, Amit Samal, Sourav Goswami, Sudheer K. Vuyyuru, Srikant Mohta, Bhaskar Kante, Peeyush Kumar, Govind Makharia, Saurabh Kedia, Tarini Shankar Ghosh, Vineet Ahuja   +11 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source