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Background. Central diabetes insipidus is characterized by the inability of the kidneys to reabsorb water and concentrate urine, which is due to the defect in the synthesis or secretion of vasopressin and is manifested by severe thirst and excretion of ...
Yu.M. Urmanova, D.I. Khamraeva
doaj +1 more source
Degradation of vasopressin precursor and pathogenic mutants in diabetes insipidus [PDF]
The nonapeptide hormone, arginine vasopressin, plays a decisive role in the regulation of fluid balance by reducing free water clearance through reabsorption of water in the renal collecting ducts.
Friberg, Michael
core +1 more source
Fibrillar aggregations of pathogenic pro-vasopressin mutants [PDF]
Diabetes insipidus is a disregulation of water homeostasis characterized by large fluid turnover in the kidney. Water homeostasis is regulated by the hormone vasopressin by increasing reapsorption of water in the renal collecting duct. Autosomal dominant
Birk, Julia
core +1 more source
Diabetes Insipidus Central: uma revisão da literatura / Central Diabetes Insipidus: a review of the literature [PDF]
Introdução: O diabetes insipidus central é uma patologia que resulta do deficit de secreção de hormônio antidiurético. A principal ação desse hormônio é regular a capacidade do rim de reabsorver água, o que explica as manifestações clínicas da doença que
Soares, Anna Luíza Lacerda +7 more
core +1 more source
FGF-21 levels in polyuria-polydipsia syndrome
The pathomechanism of primary polydipsia is poorly understood. Recent animal data reported a connection between fibroblast growth factor 21 (FGF-21) and elevated fluid intake independently of hormonal control by the hormone arginine-vasopressin (AVP) and
Julie Refardt +8 more
doaj +1 more source
Thunderclap headache caused by a pituitary non-functioning tumour presenting as spontaneous pituitary apoplexy [PDF]
Hemorrhagic or ischemic pituitary apoplexy is a rare neuro-endocrine emergency, potentially leading to coma. Neuro-ophthalmic symptoms or complications are amongst the most prevalent clinical features at onset, especially in previously asymptomatic ...
Carmen Georgescu +5 more
doaj +1 more source
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Central Diabetes Insipidus in Langerhans Cell Histiocytosis: A Case Report [PDF]
Background: Diabetes insipidus (DI) is part of a group of hereditary or acquired polyuria and polydipsia diseases. Diabetes insipidus can be caused by central and nephrogenic disorders.
Eka Agustia Rini, Lestari, Dya Mulya
core +1 more source
Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial.
Arima, Hiroshi +3 more
openaire +2 more sources
An unusual complication of snake bite
Anterior pituitary hypofunction is a well-known complication following snake bite. However, central diabetes insipidus as a complication of snake bite is only rarely reported in the literature. We are reporting a case of central diabetes insipidus, which
Mary Grace, K C Shanoj
doaj +1 more source

